ArticleCurrent biology : CB2020
Non-canonical Receptive Field Properties and Neuromodulation of Feature-Detecting Neurons in Flies.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- An inhibitory brainstem pathway reduces visual detection during background motion.Nature communications · 2026Article
- Spatial and morphological organization of mitochondria in neurons across a connectome.Science (New York, N.Y.) · 2026Article
- Visual circuitry for distance estimation in Drosophila.Current biology : CB · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inJournal of neurophysiology · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inbioRxiv : the preprint server for biology · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila.Nature communications · 2025Article
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- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
- Mating proximity blinds threat perception.Nature · 2024Article
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- Constitutive and Conditional Epitope Tagging of Endogenous G-Protein-Coupled Receptors inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body.Nature communications · 2024Article
- Article
- Social state gates vision using three circuit mechanisms inbioRxiv : the preprint server for biology · 2024Article
- Diversity of visual inputs to Kenyon cells of thebioRxiv : the preprint server for biology · 2023Article
- Visual feedback neurons fine-tune Drosophila male courtship via GABA-mediated inhibition.Current biology : CB · 2023Article
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- A Visual Pathway into Central Complex for High-Frequency Motion-Defined Bars inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Several fundamental aspects of motion vision circuitry are prevalent across flies and mice. Both taxa segregate ON and OFF signals. For any given spatial pattern, motion detectors in both taxa are tuned to speed, selective for one of four cardinal directions, and modulated by catecholamine neurotransmitters. These similarities represent conserved, canonical properties of the functional circuits and computational algorithms for motion vision. Less is known about feature detectors, including how receptive field properties differ from the motion pathway or whether they are under neuromodulatory control to impart functional plasticity for the detection of salient objects from a moving background. Here, we investigated 19 types of putative feature selective lobula columnar (LC) neurons in the optic lobe of the fruit fly Drosophila melanogaster to characterize divergent properties of feature selection. We identified LC12 and LC15 as feature detectors. LC15 encodes moving bars, whereas LC12 is selective for the motion of discrete objects, mostly independent of size. Neither is selective for contrast polarity, speed, or direction, highlighting key differences in the underlying algorithms for feature detection and motion vision. We show that the onset of background motion suppresses object responses by LC12 and LC15. Surprisingly, the application of octopamine, which is released during flight, reverses the suppressive influence of background motion, rendering both LCs able to track moving objects superimposed against background motion. Our results provide a comparative framework for the function and modulation of feature detectors and new insights into the underlying neuronal mechanisms involved in visual feature detection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.