ReviewChemistry (Weinheim an der Bergstrasse, Germany)2020
Germacrene A-A Central Intermediate in Sesquiterpene Biosynthesis.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase-Like Genes From Springtails.Angewandte Chemie (International ed. in English) · 2026Article
- Reprogramming product selectivity and activity in promiscuous terpene synthases via substrate conformation engineering.Nature communications · 2026Article
- Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution.ACS chemical biology · 2026Article
- Biosynthetic formation of the 6/7/5-odyverdiene diterpenes via a 6/10-ACS catalysis · 2026Article
- Metabolites associated with endophytic fungi in agarwood: fungal compounds and host metabolites triggered by fungi.Mycology · 2026Review
- EngineeringSynthetic and systems biotechnology · 2025Article
- Characterization of the Cubamyces Menziesii Terpenome.Chembiochem : a European journal of chemical biology · 2025Article
- Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor.ACS central science · 2025Article
- Characterization and functional reconstruction of a highly productive germacrene A synthase from Liriodendron chinense.Plant biotechnology journal · 2025Article
- Cloning and functional identification of sesquiterpene synthase geneFrontiers in plant science · 2025Article
- Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications-A Comprehensive Overview.Molecules (Basel, Switzerland) · 2024Review
- Recent advances in lycopene and germacrene a biosynthesis and their role as antineoplastic drugs.World journal of microbiology & biotechnology · 2024Review
- Article
- Stability trends in carbocation intermediates stemming from germacrene A and hedycaryol.Beilstein journal of organic chemistry · 2024Article
- Sesquiterpenes and Sesquiterpene Derivatives fromAntioxidants (Basel, Switzerland) · 2023Review
- Genomic Based Analysis of the Biocontrol SpeciesJournal of fungi (Basel, Switzerland) · 2023Article
- Plant terpene specialized metabolism: complex networks or simple linear pathways?The Plant journal : for cell and molecular biology · 2023Review
- Mode of action, chemistry and defensive efficacy of the osmeterium in the caterpillar Battus polydamas archidamas.Scientific reports · 2023Article
- Germacrene B - a central intermediate in sesquiterpene biosynthesis.Beilstein journal of organic chemistry · 2023Review
- Functional characterisation of twelve terpene synthases from actinobacteria.Beilstein journal of organic chemistry · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarises known sesquiterpenes whose biosyntheses proceed through the intermediate germacrene A. First, the occurrence and biosynthesis of germacrene A in Nature and its peculiar chemistry will be highlighted, followed by a discussion of 6-6 and 5-7 bicyclic compounds and their more complex derivatives. For each compound the absolute configuration, if it is known, and the reasoning for its assignment is presented.
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Registered trials
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