ArticleEmerging infectious diseases2020
Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010-2017
Article in Emerging infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.BMJ open · 2022Pooled it
- [Research progress on toxic shock syndrome due to group AZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Beta-Thalassemia Major Complicated by Streptococcal Toxic Shock Syndrome: A Rare Case of Survival and Successful Management.Case reports in hematology · 2026Article
- Case Report: Fulminant shock due to PVL-positiveFrontiers in medicine · 2026Article
- Polyclonal Vβ21.3 expansion in multisystem inflammatory syndrome in children despite SARS-CoV-2 vaccination.RMD open · 2025Article
- Clinical Profile, Intensive Care Needs, and Short-Term Outcome of Toxic Shock Syndrome Among Children: A 10-Year Single-Centre Experience from North India.Indian journal of pediatrics · 2023Article
- Comparison of Characteristics and Outcomes of Multisystem Inflammatory Syndrome, Kawasaki Disease and Toxic Shock Syndrome in Children.Medicina (Kaunas, Lithuania) · 2023Observational
- Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis.Frontiers in immunology · 2022Article
- A Rare Case of Staphylococcal Toxic Shock Syndrome in a Neonate.Case reports in infectious diseases · 2022Article
- Management of COVID-19-associated multisystem inflammatory syndrome in children: A comprehensive literature review.Progress in pediatric cardiology · 2021Review
- Nailfold capillaroscopy: A sensitive method for evaluating microvascular involvement in children with SARS-CoV-2 infection.Microvascular research · 2021Article
- HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children.The Journal of clinical investigation · 2021Article
- Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome.bioRxiv : the preprint server for biology · 2020Article
- Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations.bioRxiv : the preprint server for biology · 2020Article
- Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis-A Critical Review of Its Pathogenesis and Treatment.Frontiers in pediatrics · 2020Review
- Pediatric Inflammatory Multisystem Syndrome and Rheumatic Diseases During SARS-CoV-2 Pandemic.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data are limited on the incidence and management of streptococcal toxic shock syndrome (TSS) and nonstreptococcal TSS in children. We aimed to define the clinical patterns of TSS at Nationwide Children's Hospital in Ohio as they relate to published criteria, diagnostic decisions, and treatment options. Through retrospective chart reviews, we identified 58 patients with TSS (27 streptococcal, 31 nonstreptococcal) during January 2010-September 2017. We observed clinical and laboratory findings that are not part of TSS criteria, such as pyuria in streptococcal TSS (50% of patients) and pulmonary involvement (85%) and coagulopathy (92%) in nonstreptococcal TSS patients. Recommended treatment with clindamycin and intravenous immunoglobulin was delayed in streptococcal TSS patients without rash (3.37 days vs. 0.87 days in patients with rash), leading to prolonged hospitalization and complications. Incorporation of additional TSS signs and symptoms would be helpful in TSS diagnosis and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.