Evidence map›Paper›PMID 32442021›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Glucose-6-phosphate dehydrogenase increases Ca

Rakhee Gupte, Vidhi Dhagia, Petra Rocic, Rikuo Ochi, Sachin A Gupte

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Insulin resistance, CaFrontiers in physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rakhee GupteDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Vidhi DhagiaDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Petra RocicDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Rikuo OchiDepartment of Pharmacology, New York Medical College, Valhalla, New York.ORCID 0000-0002-8790-4496
Sachin A GupteDepartment of Pharmacology, New York Medical College, Valhalla, New York.
New York Medical College · US

Funding

Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5M
Regulation of Vascular Smooth Muscle Calcium by NADPH RedoxR01HL085352 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI GUPTE, SACHIN A · 2008 to 2012
$1.9M
NHLBI NIH HHS R01 HL085352NHLBI NIH HHS R01 HL132574
6 · The paper itself

Abstract

Pyridine nucleotides, such as NADPH and NADH, are emerging as critical players in the regulation of heart and vascular function. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, is the primary source and regulator of cellular NADPH. In the current study, we have identified two isoforms of G6PD (slow and fast migrating) and functionally characterized the slow migrating isoform of G6PD (G6PD

Indexed as

Action PotentialsAndrosteroneAnimalsArteriesBlood PressureCalcium Channels, L-TypeCattleCaveolaeCells, CulturedEnzyme InhibitorsGlucosephosphate DehydrogenaseHEK293 CellsHumansIsoenzymesMaleMiceAndrosteroneCalcium Channels, L-TypeEnzyme InhibitorsGlucosephosphate DehydrogenaseIsoenzymesL-type calcium channel alpha(1C)diabeteshumanion channelsNADPH

Identifiers

PMID32442021
PMCPMC7474437
OpenAlexW3027604777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.