ArticleThoracic cancer2020
Definitive lobectomy without frozen section analysis is a treatment option for large or deep nodules selected carefully with clinical diagnosis of malignancy.
Article in Thoracic cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Radiologists' diagnostic confidence in surgically referred pulmonary nodules: a routine computed tomography report retrospective analysis.BMC pulmonary medicine · 2026Article
- Does the positron emission tomography-computed tomography decrease the risk of thoracoscopic lobectomy for benign disease?-a propensity score matched cohort study.Journal of thoracic disease · 2026Article
- Development and validation of a nomogram for preoperative prediction of the invasiveness of stage T1 lung adenocarcinoma utilizing AI-driven radiomics.BMC cancer · 2026Article
- Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing.General thoracic and cardiovascular surgery · 2025Article
- Exploring the optimal threshold of 3D consolidation tumor ratio value segmentation based on artificial intelligence for predicting the invasive degree of T1 lung adenocarcinoma.Quantitative imaging in medicine and surgery · 2024Article
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- Intraoperative rapid immunohistochemistry with noncontact antibody mixing for undiagnosed pulmonary tumors.Cancer science · 2023Observational
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- Surgery without preoperative histological confirmation of lung cancer: what is the current clinical practice?Journal of thoracic disease · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue harvesting for patients with a lung nodule is sometimes unsuitable due to the size and location of the nodule. In such cases, it is unclear whether it is acceptable to proceed to definitive lobectomy without intraoperative frozen section analysis.
methodsWe retrospectively reviewed patients who underwent definitive lobectomy or wedge resection for frozen section analysis at our institution between 2014 and 2018. The sensitivity, specificity, and accuracies of the clinical and frozen section diagnoses were evaluated against the final pathological diagnosis.
resultsThere were 141 patients in the definitive lobectomy group and 58 patients in the frozen section analysis group, with the latter having smaller and less deep nodules and a lower rate of malignancy on clinical and final pathological diagnoses. The sensitivity, specificity, and accuracy of the clinical diagnosis were 100%, 82%, and 95%, respectively, in the frozen section analysis group and 99%, 67%, and 97%, respectively, in the definitive lobectomy group; values of frozen section diagnosis were 98%, 82%, and 93%, respectively. On subgroup analysis, all ground-glass nodules clinically diagnosed as malignant had a final pathological diagnosis of malignancy.
conclusionsThe accuracy of the clinical diagnosis was high and was not inferior to the frozen section diagnosis. These data suggest that definitive lobectomy is an acceptable treatment option for carefully selected patients with large or deep nodules and ground-glass nodules clinically diagnosed as malignant. To avoid unnecessary lobectomy, frozen section diagnosis should be considered for nodules likely to be benign. KEY POINTS: Significant findings of the study The accuracy of the clinical diagnosis was high and was not inferior to the frozen section diagnosis. What this study adds Definitive lobectomy is an acceptable treatment option for carefully selected patients with large or deep nodules and ground-glass nodules with a clinical diagnosis of malignancy.
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