ArticleAngewandte Chemie (International ed. in English)2020
Absolute Configuration of Small Molecules by Co-Crystallization.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- An Adaptable Porous Metal-Organic Framework for Structural Visualization of Beyond Rule of 5 Molecules on the Microgram Scale.Journal of the American Chemical Society · 2026Article
- Machine Learning Accelerates Crystallization for Structure Determination.Angewandte Chemie (International ed. in English) · 2026Article
- Enhanced crystallinity of tetrahalopyridyl (THP) derivatized compounds.Chemical science · 2026Article
- Functionality-Matched Semicarbazone Reagents Allow Access to X-ray Quality Crystals and Solids of Diverse Organic Molecules.Organic letters · 2026Article
- Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules.Angewandte Chemie (International ed. in English) · 2026Article
- Getting crystals your crystallographer will treasure: a beginner's guide.Acta crystallographica. Section E, Crystallographic communications · 2025Article
- What Makes a Branched Aromatic Compound a Crystallization Chaperone? Insights from a Comparison of Three Organic Scaffolds.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Absolute Configuration and Chiroptical Properties of Flexible Drug Avapritinib.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Engineering Lipophilic Aggregation of Adapalene and Adamantane-Based Cocrystals via van der Waals Forces and Hydrogen Bonding.Crystal growth & design · 2024Article
- Host-Guest Cocrystallization of Phenanthrene[2]arene Macrocycles Facilitating Structure Determination of Liquid Organic Molecules.Molecules (Basel, Switzerland) · 2024Article
- Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests.ACS materials letters · 2024Article
- Atomic-resolution structure analysis inside an adaptable porous framework.Nature communications · 2024Article
- Host-guest system of a phosphorylated macrocycle assisting structure determination of oily molecules in single-crystal form.Chemical science · 2023Article
- Approaches to Configuration Determinations of Flexible Marine Natural Products: Advances and Prospects.Marine drugs · 2022Review
- Absolute configuration determination of pharmaceutical crystalline powders by MicroEDChemical communications (Cambridge, England) · 2022Article
- Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization.RSC advances · 2022Article
- Co-crystallization of an organic solid and a tetraaryladamantane at room temperature.Beilstein journal of organic chemistry · 2021Article
- Absolute Configuration of Small Molecules by Co-Crystallization.Angewandte Chemie (International ed. in English) · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most reliable method to determine the absolute configuration of chiral molecules is X-ray crystallography, but small molecules can be difficult to crystallize. We report rapid co-crystallization of tetraaryladamantanes with small molecules as different as n-decane to nicotine to produce crystals for X-ray analysis and the assignment of absolute configuration when the molecules are chiral. A screen of 52 diverse compounds gave inclusion in co-crystals for 88 % of all cases and a high-resolution structure in 77 % of cases. Furthermore, starting from three milligrams of analyte, a combination of NMR spectroscopy and X-ray crystallography produced a full structure in less than three days using an adamantane crystallization chaperone that encapsulates the analyte at room temperature.
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