Evidence map›Paper›PMID 32441786›Full record

ArticleJournal of medical virology2020

Effects of methylprednisolone use on viral genomic nucleic acid negative conversion and CT imaging lesion absorption in COVID-19 patients under 50 years old.

Yuan Gong, Li Guan, Zhu Jin, Shixiong Chen, Guangming Xiang, Baoan Gao

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 7 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  8. Article
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  10. Effects of dexamethasone use on viral clearance among patients with COVID-19: a multicenter cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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  11. Article
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  14. Article
  15. Unraveling the Relationship of Asthma and COVID-19.Journal of personalized medicine · 2021
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  17. Inflammation, immunity and potential target therapy of SARS-COV-2: A total scale analysis review.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuan GongDepartment of Medicine and Respiratory, First Clinical Medical College of Three Gorges University, Yi Chang Central People's Hospital, Institute of Respiratory Diseases, Three Gorges University, Xiling, Yichang, Hubei, China.ORCID 0000-0003-3268-2379
Li GuanDepartment of Medicine and Respiratory, First Clinical Medical College of Three Gorges University, Yi Chang Central People's Hospital, Institute of Respiratory Diseases, Three Gorges University, Xiling, Yichang, Hubei, China.
Zhu JinDepartment of Medicine and Respiratory, First Clinical Medical College of Three Gorges University, Yi Chang Central People's Hospital, Institute of Respiratory Diseases, Three Gorges University, Xiling, Yichang, Hubei, China.
Shixiong ChenDepartment of Medicine and Respiratory, First Clinical Medical College of Three Gorges University, Yi Chang Central People's Hospital, Institute of Respiratory Diseases, Three Gorges University, Xiling, Yichang, Hubei, China.
Guangming XiangDepartment of Medicine and Respiratory, First Clinical Medical College of Three Gorges University, Yi Chang Central People's Hospital, Institute of Respiratory Diseases, Three Gorges University, Xiling, Yichang, Hubei, China.
Baoan GaoDepartment of Medicine and Respiratory, First Clinical Medical College of Three Gorges University, Yi Chang Central People's Hospital, Institute of Respiratory Diseases, Three Gorges University, Xiling, Yichang, Hubei, China.
China Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of corticosteroids has been controversial in viral pneumonia. In most cases, application of methylprednisolone in severe and critical viral pneumonia patients can quickly alleviate the symptoms of dyspnea and prevent disease progression. However, some scholars have confirmed that corticosteroids delayed the body's clearance of the virus. In our retrospective non-randomized study, 34 patients under 50 years old and diagnosed with coronavirus disease 2019 (COVID-19) were included. According to the given methylprednisolone treatment (n = 18) or not (n = 16), they were separated into two groups. By comparing the clinical data we concluded that corticosteroids therapy can effectively release COVID-19 symptoms such as persistent fever and difficult in breathing, improve oxygenation, and prevent disease progression. However, it can prolong the negative conversion of nucleic acids.

Indexed as

COVID-19 Drug TreatmentAdrenal Cortex HormonesAdultCOVID-19Disease ProgressionFemaleGenomicsHumansLungMaleMethylprednisoloneMiddle AgedRetrospective StudiesSARS-CoV-2Tomography, X-Ray ComputedTreatment OutcomeAdrenal Cortex HormonesMethylprednisoloneCOVID-19CT image lesionmethylprednisolonetreatmentvirus nucleic acid

Identifiers

PMID32441786
PMCPMC7280598
OpenAlexW3026813438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.