Evidence map›Paper›PMID 32441784›Full record

ArticleJPEN. Journal of parenteral and enteral nutrition2021

Impact of Clinical Factors on the Intestinal Microbiome in Infants With Gastroschisis.

Allison J Wu, David J Lee, Fan Li, Nicole H Tobin, Grace M Aldrovandi, Stephen B Shew, Kara L Calkins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JPEN. Journal of parenteral and enteral nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Interval growth across gestation in pregnancies with fetal gastroschisis.American journal of obstetrics & gynecology MFM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Allison J WuDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-3162-5439
David J LeeDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Fan LiDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Nicole H TobinDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Grace M AldrovandiDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Stephen B ShewDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Kara L CalkinsDepartment of Pediatrics, Neonatal Research Center of the UCLA of Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA and UCLA Mattel Children's Hospital, Los Angeles, California, USA.ORCID 0000-0001-6658-7981
University of California, Los Angeles · USBoston Children's Hospital · USMattel Children's Hospital · USPalo Alto University · US

Funding

The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
UCLA Clinical and Translational Science InstituteKL2TR000122 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$4.5M
NCATS NIH HHS KL2 TR000122NCATS NIH HHS KL2 TR001882NIH/NCATS KL2TR000122
6 · The paper itself

Abstract

backgroundInfants with gastroschisis require operations and lengthy hospitalizations due to intestinal dysmotility. Dysbiosis may contribute to these problems. Little is known on the microbiome of gastroschisis infants.

methodsThe purpose of this study was to investigate the fecal microbiome in gastroschisis infants. Microbiome profiling was performed by sequencing the V4 region of the 16S rRNA gene. The microbiome of gastroschisis infants was compared with the microbiome of healthy controls, and the effects of mode of birth delivery, gestational age, antibiotic duration, and nutrition type on microbial composition and diversity were investigated.

resultsThe microbiome of gastroschisis infants (n = 13) was less diverse (Chao1, P < .001), lacked Bifidobacterium (P = .001), and had increased Staphylococcus (P = .007) compared with controls (n = 83). Mode of delivery (R

conclusionThe microbiome of gastroschisis infants is dysbiotic, and mode of birth delivery, antibiotic duration, and gestational age appear to contribute to microbial variation.

Indexed as

Gastrointestinal MicrobiomeGastroschisisCesarean SectionDysbiosisFemaleHumansInfantPregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16Sgastroenterologymicrobiomepediatrics

Identifiers

PMID32441784
PMCPMC9197548
OpenAlexW3027100437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.