ArticleJournal of periodontology2020
Shifting the paradigm from inhibitors of inflammation to resolvers of inflammation in periodontitis.
Article in Journal of periodontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 79 citations in OpenAlex.
- Type I interferon-induced CD169Journal of periodontology · 2026Article
- Inhibition of periodontitis progression by a non-steroidal inhibitor of steroid sulfatase in healing-impaired conditions: a preclinical rodent model pilot experiment.Journal of periodontal & implant science · 2026Article
- Immunomodulation Strategies in Oral Diseases: From Microbiome Manipulation to Pro-resolution Therapies.Advances in experimental medicine and biology · 2026Review
- The role of omega-3 polyunsaturated fatty acids in the non-surgical management of periodontitis: a systematic review and meta-analysis.Frontiers in oral health · 2026Review
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Population-Based Structural Evidence: Triadic Effects of Periodontitis, Depression, and Biological Aging on Cognitive Health.Gerontology · 2026Article
- Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- JAK Inhibition Prevents Bone Loss and Reduces Inflammation in Experimental Periodontitis.Journal of periodontal research · 2025Article
- Comprehensive Analysis of Sialylation-Related Gene Profiles and Their Impact on the Immune Microenvironment in Periodontitis.Inflammation · 2025Article
- Fatty Acid Binding Protein 4 Could Be a Linking Biomarker Between Periodontitis and Systemic Diseases.Biomedicines · 2025Article
- Interaction of the Systemic Inflammatory State, Inflammatory Mediators, and the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Evaluating the Association Between Neutrophil Gelatinase-Associated Lipocalin Levels and Periodontal Health Status in Patients With Chronic Kidney Disease.Mediators of inflammation · 2025Article
- The Application of Resolvin D1-Loaded Gelatin Methacrylate in a Rat Periodontitis Model.Pharmaceutics · 2024Article
- Matrix Metalloproteinase 9 (MMP-9) and Interleukin-8 (IL-8) in Gingival Crevicular Fluid after Minimally Invasive Periodontal Surgery with or without Er:YAG and Nd:YAG Laser Application.Antibiotics (Basel, Switzerland) · 2024Article
- Global trends in research on aging associated with periodontitis from 2002 to 2023: a bibliometric analysis.Frontiers in endocrinology · 2024Article
- Host modulation therapy in periodontitis, diagnosis and treatment-status update.Frontiers in dental medicine · 2024Article
- The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications.Frontiers in immunology · 2024Review
- Crosstalk between periodontitis and cardiovascular risk.Frontiers in immunology · 2024Review
- Disruptive innovation events in dentistry.JADA foundational science · 2024Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
An initial shift in our understanding of the basis of periodontal disease occurred early in the 2000s. The host response, rather than the bacterial burden, was the principal determinant of the disease. Microbial dysbiosis that occurs in periodontal disease results from a hyperinflammatory state in the host. A second shift in periodontal disease is taking place. This time in the realm of treatment strategies. Rather than targeting antimicrobials or inhibitors of individual inflammatory mediators, preclinical studies support using resolution pharmacology to convert the pro-inflammatory condition into a non-inflammatory one, thereby resolving both the local and systemic inflammation associated with periodontal disease. Here, I describe the bases for these shifts in paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.