ArticleJournal of the American Geriatrics Society2020
The Relationship between Polypharmacy and Physical Activity in Those with or at Risk of Knee Osteoarthritis.
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study.Brain stimulationTrial
- Optimizing polypharmacy management in older adults: impact of an interdisciplinary outpatient clinic on long-term function and quality of life.European geriatric medicine · 2026Observational
- Association Between Polypharmacy and Physical Function in Middle-aged Adults: Findings from the CARDIA Function Study.Journal of general internal medicine · 2026Article
- Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response.bioRxiv : the preprint server for biology · 2025Article
- Joint Pain and Leisure-Time Physical Activity: Cross-Sectional Findings From the Cardiovascular Health Study.Health science reports · 2025Article
- Effect modification of polypharmacy on incident frailty by chronic kidney disease in older adults.BMC geriatrics · 2024Article
- Polypharmacy Is Associated with Sociodemographic Factors and Socioeconomic Status in United States Adults.Pharmacy (Basel, Switzerland) · 2024Article
- Objectively evaluated physical activity among individuals following anterior cruciate ligament reconstruction: a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2024Article
- An alternative treatment option in older adults with knee osteoarthritis : Genicular nerve pulsed radiofrequency.Wiener klinische Wochenschrift · 2023Article
- Leisure-time physical activity and sarcopenia among older adults from low- and middle-income countries.Journal of cachexia, sarcopenia and muscle · 2023Article
- Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative.Clinical rheumatology · 2022Review
- Medical history, medication use and physical activity in adults in their eighth and ninth decade of life in the Hertfordshire Cohort Study.EXCLI journal · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesPhysical activity is associated with improved pain, functional status, and less disability in persons with knee osteoarthritis (KOA). Because polypharmacy is related to several adverse health outcomes in older persons, we hypothesized that it might also be associated with decreased physical activity in those with KOA. This study evaluates the relationship between the number of prescription medications and weekly moderate to vigorous physical activity (MVPA).
designWe used hierarchical median quantile regression analysis to examine the cross-sectional association between the number of prescription medications taken in the past 30 days and the median objectively measured MVPA minutes controlling for demographic and clinical variables.
settingFour Osteoarthritis Initiative (OAI) recruitment centers in Providence, Rhode Island; Columbus, Ohio; Baltimore, Maryland; and Pittsburgh, Pennsylvania.
participantsAccelerometer monitoring occurred in 2,127 OAI participants. Of these, 1,889 participants had 4 or more days of valid physical activity monitoring data and complete medication/covariate data. Data were collected at the 48-month OAI follow-up visit (2008-2010). MEASUREMENTS: The outcome was weekly minutes of MVPA measured with an accelerometer. Number/type of prescribed medications and covariate data (age, sex, race/ethnicity, body mass index, presence of comorbidities, pain, depressive symptoms, and radiographic KOA severity) were taken from the public OAI database. Polypharmacy was defined as taking five or more prescribed medications.
resultsThe prevalence of polypharmacy in the study population was 28.2%. Each additional prescription medication was related to a decrease of 3.6 minutes (95% confidence interval [CI] = -4.8 to -2.1) in median weekly MVPA minutes. Participants meeting the polypharmacy criterion exhibited a decrease of 12.6 minutes (95% CI = -21.2 to -4.7) in median weekly MVPA minutes compared with those not meeting the criterion.
conclusionAn increased number of prescription medications and polypharmacy are associated cross-sectionally with decreased MVPA in adults with KOA. Further study is necessary to establish the causal nature of this association.
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