ArticleSocial cognitive and affective neuroscience2020
Systemic inflammation is associated with differential neural reactivity and connectivity to affective images.
Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurobiological effects of microbial treatments within psychiatry: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Cumulative trauma, neural circuits, and burnout: an integrative model of healthcare worker post-traumatic stress syndromes.European journal of psychotraumatology · 2026Review
- Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls.Molecular psychiatry · 2026Article
- Loneliness exacerbates age differences in the -allostatic-interoceptive system during induced affect.Social cognitive and affective neuroscience · 2026Article
- Neuroinflammation and treatment resistance in major depressive disorder.Frontiers in pharmacology · 2026Review
- Effects of Pollution Burden on Neural Function During Implicit Emotion Regulation and Longitudinal Changes in Depressive Symptoms in Adolescents.Biological psychiatry global open science · 2024Article
- Neutrophil-Lymphocyte Ratio Values in Schizophrenia: A Comparison between Oral and Long-Acting Antipsychotic Therapies.Brain sciences · 2024Article
- Discrimination and Cardiovascular Health in Black Americans: Exploring Inflammation as a Mechanism and Perceived Control as a Protective Factor.Psychosomatic medicine · 2024Article
- The roles of inflammation, affect, and interoception in predicting social perception.Brain, behavior, and immunity · 2023Article
- Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions.Frontiers in psychiatry · 2023Article
- From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review.International journal of molecular sciences · 2022Review
- Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents.Brain, behavior, and immunity · 2022Article
- Early life stress, systemic inflammation, and neural correlates of implicit emotion regulation in adolescents.Brain, behavior, and immunity · 2022Article
- Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms.Brain, behavior, & immunity - health · 2022Article
- What's Playing in Your Waiting Room? Patient and Provider Stress and the Impact of Waiting Room Media.Journal of patient experience · 2021Article
- Health neuroscience 2.0: integration with social, cognitive and affective neuroscience.Social cognitive and affective neuroscience · 2020Article
- Aging as a Context for the Role of Inflammation in Depressive Symptoms.Frontiers in psychiatry · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Systemic inflammation is increasingly appreciated as a predictor of health and well-being. Further, inflammation has been shown to influence and be influenced by affective experiences. Although prior work has substantiated associations between inflammatory and affective processes, fewer studies have investigated the neurobiological correlates that underlie links between systemic, low-grade inflammation and affective reactivity. Thus, the current study examined whether markers of systemic inflammation (i.e. interleukin-6, C-reactive protein) are associated with differential patterns of neural activation and connectivity in corticolimbic regions in response to affective images. We investigated this question in a sample of 66 adults (44 women, M age = 54.98 years, range = 35-76) from the Midlife in the United States study. Higher levels of inflammation were associated with lower activity in limbic regions (i.e. amygdala, hippocampus, anterior insula, temporal pole) when viewing positive (vs neutral) images. Higher levels of inflammation were also associated with greater connectivity between the hippocampus and the medial prefrontal cortex in response to positive images. Inflammatory markers were not associated with significant differences in activation or connectivity to negative images. These findings highlight the utility of health neuroscience approaches in demonstrating that physiological processes such as inflammation are related to how our brains respond to affective information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.