Evidence map›Paper›PMID 32441303›Full record

ArticleAmerican journal of clinical pathology2020

Placental Pathology in COVID-19.

Elisheva D Shanes, Leena B Mithal, Sebastian Otero, Hooman A Azad, Emily S Miller, Jeffery A Goldstein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 356 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
356citing papers in PubMed, 9 pooled it
51.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

356 citing papers in PubMed, 9 syntheses or guidelines pooled it, 626 citations in OpenAlex.

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  4. COVID-19 and Preeclampsia: A Systematic Review of Pathophysiological Interactions.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023
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296 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elisheva D ShanesDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Leena B MithalDepartment of Pediatrics, Division of Infectious Diseases, Ann and Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, IL.
Sebastian OteroDepartment of Pediatrics, Division of Infectious Diseases, Ann and Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, IL.
Hooman A AzadFeinberg School of Medicine, Northwestern University, Chicago, IL.
Emily S MillerDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Jeffery A GoldsteinDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
NCATS NIH HHS UL1 TR001422
6 · The paper itself

Abstract

objectivesTo describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy.

methodsPregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma.

resultsSixteen placentas from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were examined (15 with live birth in the third trimester, 1 delivered in the second trimester after intrauterine fetal demise). Compared to controls, third trimester placentas were significantly more likely to show at least one feature of maternal vascular malperfusion (MVM), particularly abnormal or injured maternal vessels, and intervillous thrombi. Rates of acute and chronic inflammation were not increased.The placenta from the patient with intrauterine fetal demise showed villous edema and a retroplacental hematoma.

conclusionsRelative to controls, COVID-19 placentas show increased prevalence of decidual arteriopathy and other features of MVM, a pattern of placental injury reflecting abnormalities in oxygenation within the intervillous space associated with adverse perinatal outcomes. Only 1 COVID-19 patient was hypertensive despite the association of MVM with hypertensive disorders and preeclampsia. These changes may reflect a systemic inflammatory or hypercoagulable state influencing placental physiology.

Indexed as

AdultBetacoronavirusCase-Control StudiesCoronavirus InfectionsCOVID-19FemaleHumansPandemicsPlacentaPneumonia, ViralPregnancyPregnancy Complications, InfectiousPregnancy Trimester, ThirdSARS-CoV-2CoronavirusCOVID-19Decidual arteriopathyIntervillous thrombiMaternal vascular malperfusionMaternal vascular underperfusionPerinatal outcomesPlacental pathologySARS-CoV-2

Identifiers

PMID32441303
PMCPMC7279066
OpenAlexW4206812716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.