Evidence map›Paper›PMID 32441020›Full record

ArticleCanadian journal of public health = Revue canadienne de sante publique2020

Associations of prenatal urinary phthalate exposure with preterm birth: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study.

Janice M Y Hu, Tye E Arbuckle, Patricia Janssen, Bruce P Lanphear, Joseph M Braun, Robert W Platt, Aimin Chen, William D Fraser, Lawrence C McCandless

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of public health = Revue canadienne de sante publique, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Janice M Y HuFaculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
Tye E ArbucklePopulation Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Canada.
Patricia JanssenSchool of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Bruce P LanphearFaculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, USA.
Robert W PlattDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Aimin ChenDepartment of Environmental Health, University of Cincinnati, Cincinnati, OH, 45221, USA.
William D FraserDepartment d'obstétrique et gynécologie, Université de Sherbrooke, Quebec, Canada.
Lawrence C McCandlessFaculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada. lmccandl@sfu.ca.
Simon Fraser University · CABrown University · USHealth Canada · CAMcGill University · CAUniversité de Sherbrooke · CAUniversity of British Columbia · CAUniversity of Cincinnati · US

Funding

CIHR L-CIP-150736CIHR MOP-81285
6 · The paper itself

Abstract

objectivesTo examine the relation between prenatal urinary phthalate metabolite concentrations and preterm birth (PTB).

methodsThe data were drawn from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pan-Canadian cohort of 1857 pregnant women enrolled between 2008 and 2011. We quantified urinary concentrations of 7 phthalate metabolites that were detected in > 70% of urine samples collected during the first trimester. Gestational age was obtained from either the last menstrual period or early ultrasound. We used Cox proportional hazard models to examine the associations of urinary phthalate metabolite concentrations, plus the molar sum of di-2-ethylhexyl phthalate metabolites (∑DEHP), with time to delivery before 37 weeks of gestation. We also examined PTB by clinical presentation. PTBs presented with either spontaneous labour or premature rupture of the membrane were considered spontaneous PTB (sPTB). Additionally, we used multiple linear regression to model changes in mean gestational age in relation to phthalate exposure.

resultsWe found no evidence of an association between first trimester phthalate metabolite concentrations and PTB among the MIREC study participants. For example, each 2-fold increase in any of the 7 phthalate concentrations or ∑DEHP was associated with hazard ratios (HRs) for PTB ranging from 0.95 to 1.07 with 95% confidence intervals including the null. An assessment of non-linear trends showed some evidence of non-monotonic dose-response relationships between phthalates and PTB. Furthermore, male infants exposed to MCPP showed higher sPTB risk compared with female infants.

conclusionPhthalate exposure during early pregnancy is not clearly associated with the risk of PTB among this Canadian population.

Indexed as

Prenatal Exposure Delayed EffectsAdultCanadaCohort StudiesFemaleHumansInfant, NewbornMalePhthalic AcidsPregnancyPregnancy Trimester, FirstPremature BirthYoung Adultphthalic acidPhthalic AcidsEnvironmental chemicalsGestational agePhthalatesPreterm birth

Identifiers

PMID32441020
PMCPMC7351891
OpenAlexW3026717525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.