Evidence map›Paper›PMID 32441013›Full record

ArticleDrug delivery and translational research2020

Design and development of polymethylmethacrylate-grafted gellan gum (PMMA-g-GG)-based pH-sensitive novel drug delivery system for antidiabetic therapy.

Rohit R Bhosale, Hosahalli V Gangadharappa, Riyaz Ali M Osmani, Devegowda V Gowda

Abstract read
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Article in Drug delivery and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Recent opportunities and application of gellan gum based drug delivery system for intranasal route.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rohit R BhosaleDepartment of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Institute of Medical Sciences Deemed To Be University, Karad, Maharashtra, 415539, India.
Hosahalli V GangadharappaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India.
Riyaz Ali M OsmaniDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, 400076, India. riyazosmani@gmail.com.ORCID 0000-0002-2333-0817
Devegowda V GowdaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India.

Funding

Department of Science and Technology, Government of India, New Delhi SR/SO/HS-0107/2016
6 · The paper itself

Abstract

The objective of the present study was to develop a pH-sensitive drug delivery system by using polymethylmethacrylate-grafted gellan gum (PMMA-g-GG). PMMA-g-GG was synthesized by free radical polymerization reaction by using redox initiator ceric ammonium nitrate (CAN), and a series of graft copolymers were prepared with varying concentrations of methylmethacrylate (MMA) and CAN. Grafting parameters such as the percentage and efficiency of grafting were calculated, and the effect of monomer as well as initiator concentration was studied on the grafting yield. Optimization was done by one optimal response surface methodology. The batch with a better percentage grafting and grafting efficiency was selected and characterized by elemental analysis (CHN), FT-IR, DSC, PXRD,

Indexed as

Drug Delivery SystemsAdministration, OralAnimalsDiabetes Mellitus, ExperimentalDrug DesignDrug LiberationFemaleHydrogen-Ion ConcentrationHypoglycemic AgentsMaleMetforminMicePolymethyl MethacrylatePolysaccharides, BacterialRats, Wistargellan gumHypoglycemic AgentsMetforminPolymethyl MethacrylatePolysaccharides, BacterialAntidiabetic therapyFree radical polymerizationGellan gumGraftingMetformin hydrochloridepH-sensitive drug delivery

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.