ArticleAdvances in therapy2020
Persistence of Inflammation After Uncomplicated Cataract Surgery: A 6-Month Laser Flare Photometry Analysis.
Article in Advances in therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03317847 (Bromfenac 0.09% Versus Dexamethasone 0.1% Ophthalmic Solutions to Reduce Inflammation After Cataract Surgery), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bromfenac 0.09% Versus Dexamethasone 0.1% Ophthalmic Solutions to Reduce Inflammation After Cataract Surgery
Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Hydrophobic and Hydrophilic IOLs in Patients with Uveitis - A Randomised Clinical Trial.Clinical ophthalmology (Auckland, N.Z.) · 2025Trial
- The Effect of Pretreatment Cataract Surgery on Selective Laser Trabeculoplasty Outcomes: A One-Year Follow-Up Study.Diseases (Basel, Switzerland) · 2026Article
- Association between systemic immune-inflammation index and postoperative optical quality in the early recovery phase after cataract surgery: a retrospective study.Frontiers in medicine · 2026Article
- Quantitative evaluation of inflammation after phacoemulsification surgery: anterior chamber flare and choroidal vascular index.Japanese journal of ophthalmology · 2025Observational
- Thermoelectric Measuring Equipment for Perioperative Monitoring of Temperature and Heat Flux Density of the Human Eye in Vitreoretinal Surgery.Sensors (Basel, Switzerland) · 2025Article
- Comparative efficacy of non-steroidal anti-inflammatory drugs in preventing postoperative macular edema following cataract surgery: a systematic review and Network Meta-analysis.International journal of ophthalmology · 2025Article
- Implications of Ocular Confounding Factors for Aqueous Humor Proteomic and Metabolomic Analyses in Retinal Diseases.Translational vision science & technology · 2024Article
- Anterior chamber flare and choroidal vascular index as inflammatory markers after uncomplicated phacoemulsification surgery.International ophthalmology · 2024Article
- Human lens epithelial cells induce the inflammatory response when placed into the lens capsular bag model of posterior capsular opacification.Molecular vision · 2024Article
- Laser Flare Photometry to Monitor Childhood Chronic Uveitis: A Preliminary Report of a Monocentric Italian Experience.Diagnostics (Basel, Switzerland) · 2023Article
- Changes in Macular Thickness after Cataract Surgery in Patients with Open Angle Glaucoma.Diagnostics (Basel, Switzerland) · 2023Article
- Macular vascular density and visual function after phacoemulsification in cataract patients with non-pathological high myopia: a prospective observational cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Observational
- Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes.Eye and vision (London, England) · 2021Article
- Laser flare and cell photometry to measure inflammation after cataract surgery: a tool to predict the risk of cystoid macular edema.International ophthalmology · 2021Review
- Epidemiology of uveitis after tuberculosis in Taiwan - A nationwide population-based cohort study.Taiwan journal of ophthalmologyArticle
- Laser flare photometry in uveitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Factors influencing aqueous flare after cataract surgery and its evaluation with laser flare photometry.Therapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate, by laser photometry, the persistency of anterior chamber flare after uneventful phacoemulsification in asymptomatic patients with no signs of inflammation on slit lamp examination.
methodSeventy-five patients previously enrolled in a randomized clinical trial that evaluated inflammation after uneventful phacoemulsification in eyes treated with dexamethasone 0.1% ophthalmic suspension (group 1) or bromfenac 0.09% ophthalmic solution (group 2) for 2 weeks. Anterior chamber inflammation was investigated by laser flare photometry. At 30 days after surgery, laser flare showed persistently elevated values. For this reason, patients were further analyzed at 3 and 6 months. Additionally, optical coherence tomography was used to measure the central macular thickness (CMT) and to assess for postoperative pseudophakic macular edema.
resultsWhen compared to preoperative values, laser flare photometry demonstrated persistent ocular inflammation at postoperative days 90 and 180 in group 1, but not in group 2. Laser flare values showed a significant reduction in group 2 compared to group 1 throughout all the follow-up (p < 0.001). The increase in mean CMT at days 90 and 180 with respect to baseline was statistically significant in group 1 but not in group 2, in which it decreased to levels similar to preoperative value. Group 1 showed a higher increase in mean CMT compared to group 2 throughout all the follow-up (p < 0.001). The proportion of patients that developed pseudophakic cystoid macular edema (CME) was 14% (n = 5) and 0% (n = 0) in group 1 and group 2, respectively (p = 0.02). The bivariate analysis demonstrated a positive correlation between laser flare and CMT values in group 1 but not in group 2.
conclusionAnterior chamber inflammation persists for more than 30 days in a significant proportion of patients after uncomplicated cataract surgery and may be responsible for late onset of cystoid macular edema cases.
trial registrationClinicalTrials.gov identifier, NCT03317847.
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