ArticlePediatric nephrology (Berlin, Germany)2020
Continuous kidney replacement therapy in critically ill neonates and infants: a retrospective analysis of clinical results with a dedicated device.
Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Novel use of the Nuwellis® dual extended length catheter (dELC) as umbilical venous access for neonatal kidney replacement therapy: case series.Pediatric nephrology (Berlin, Germany) · 2026Article
- Continuous kidney replacement therapy in low birth weight and premature neonates-are we entering a new era?Pediatric nephrology (Berlin, Germany) · 2026Article
- Real-world modality selection and outcomes in neonatal kidney replacement therapy: a single-center cohort study.European journal of pediatrics · 2026Article
- Continuous kidney replacement therapy with CARPEDIEMPediatric nephrology (Berlin, Germany) · 2026Article
- Early continuous renal replacement therapy for acute kidney injury in a very low birth weight infant: a case report and literature review.Frontiers in medicine · 2026Article
- Renal replacement therapy in intensive care unit: a narrative review.Annals of intensive care · 2026Review
- Evaluation of anticoagulant methods in newborns undergoing continuous renal replacement therapy: what is the optimum method?European journal of pediatrics · 2025Article
- Bioethical issues in neonatal care: the case of CARPEDIEM.European journal of pediatrics · 2025Review
- AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework.Frontiers in pediatrics · 2025Review
- Continuous Renal Replacement Therapy Guided by Bedside Ultrasound in an Extremely Low Birth Weight Infant.Indian journal of pediatrics · 2024Article
- Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system.Pediatric nephrology (Berlin, Germany) · 2024Observational
- New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Article
- Real-life effects, complications, and outcomes in 39 critically ill neonates receiving continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2023Article
- CARPEDIEM® for continuous kidney replacement therapy in neonates and small infants: a French multicenter retrospective study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Regional citrate anticoagulation for continuous renal replacement therapy in newborns.Frontiers in pediatrics · 2023Article
- Optimal stage of initiating continuous renal replacement therapy in the treatment of neonatal acute kidney injury.Experimental and therapeutic medicine · 2022Article
- Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury.Intensive care medicine · 2022Review
- Mortality Risk Factors among Infants Receiving Dialysis in the Neonatal Intensive Care Unit.The Journal of pediatrics · 2022Article
- Survival of infants treated with CKRT: comparing adapted adult platforms with the Carpediem™.Pediatric nephrology (Berlin, Germany) · 2022Article
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProviding extracorporeal renal support to neonates and infants involves a number of technical and clinical issues, possibly discouraging early utilization. This report aims to describe a multicenter experience of continuous kidney replacement therapy (CKRT) delivery to small infants using a device specifically designed for this age group.
methodsA retrospective cohort analysis of all patients treated with the Carpediem™ machine (Bellco-Medtronic, Mirandola, Italy) in 6 centers between June 2013 and December 2016.
resultsTwenty-six neonates and small infants received 165 CKRT sessions in convective modality. Median age at neonatal intensive care unit admission 1 day (IQR 1-11), median body weight 2.9 kg (IQR 2.2-3.6). Median circuit duration 14 h (IQR 10-22), with delivered/prescribed time ratio of 84%. CKRT was conducted using 4 Fr (27%), 5 Fr (35%), 6.5 Fr (11%), and 7 Fr (3%) vascular access, and with umbilical and peripheral accesses (11% each) allowing overall median blood flow of 4.5 ml/kg/min (IQR 3.4-6) and median effluent flow rate 35 ml/kg/h (IQR 28-42). Circuits were primed with normal saline in 58% of treatments, colloids in 31%, and packed red blood cells in 11%. No serious adverse events directly related to machine application were reported by any center. Twenty-five (96%) patients survived their CKRT course and 13 patients (50%) survived to ICU discharge.
conclusionsCKRT in neonates was easy to initiate and conduct when performed with small central vascular accesses coupled with this device. A dedicated technology for infant CKRT delivery enables patients to be safely treated avoiding technical complications. Graphical abstract.
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