Evidence map›Paper›PMID 32440919›Full record

ArticleJournal of neurology2020

Dopaminergic function in spinocerebellar ataxia type 6 patients with and without parkinsonism.

Yoshihiko Horimoto, Emi Hayashi, Yoshihiro Ito, Akihiko Iida, Yoji Goto, Shigenori Kato, Kenji Okita, Tetsuharu Kako, Chikako Sato, Toshihisa Tajima and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Tremor in Spinocerebellar Ataxia: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Yoshihiko HorimotoDepartment of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan. holly@nagoya-rehab.or.jp.ORCID http://orcid.org/0000-0002-5133-281X
Emi HayashiDepartment of Radiology, Nagoya City Rehabilitation Center, Nagoya, Japan.
Yoshihiro ItoDepartment of Radiology, Nagoya City Rehabilitation Center, Nagoya, Japan.
Akihiko IidaDepartment of Radiology, Nagoya City Rehabilitation Center, Nagoya, Japan.
Yoji GotoDepartment of Neurology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan.
Shigenori KatoDepartment of Neurology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan.
Kenji OkitaDepartment of Neurology, Nagoya City University, Nagoya, Japan.
Tetsuharu KakoDepartment of Neurology, Bantane Hospital, Fujita Health University, Nagoya, Japan.
Chikako SatoDepartment of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan.
Toshihisa TajimaDepartment of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan.
Aki InagakiDepartment of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan.
Kazuya NokuraDepartment of Neurology, Bantane Hospital, Fujita Health University, Nagoya, Japan.
Hiroaki HibinoDepartment of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan.
Noriyuki MatsukawaDepartment of Neurology, Nagoya City University, Nagoya, Japan.
Kazuo YamadaDepartment of Neurosurgery, Nagoya City Rehabilitation Center, Nagoya, Japan.
Hidehiro KabasawaDepartment of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan.
Nagoya City University · JPFujita Health University Hospital · JPJapanese Red Cross Nagoya Daiichi Hospital · JPJapanese Red Cross Nagoya Daini Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough pure cerebellar ataxia is usually emphasized as the characteristic clinical feature of spinocerebellar ataxia type 6 (SCA6), parkinsonism has been repeatedly described in patients with genetically confirmed SCA6.

methodsWe conducted a positron emission tomography study using a combination of [

resultsMost patients had somewhat decreased dopaminergic function, and this decrease was significant in the caudate nucleus. In addition, one SCA6 patient with parkinsonism had whole striatal dysfunction of both dopamine synthesis and dopamine D2 receptor function.

conclusionsThe pathology of SCA6 may not be restricted to the cerebellum, but may also be distributed across various regions, including in both presynaptic and postsynaptic dopaminergic neurons to some degree. Patients with SCA6 may show apparent parkinsonism after the progression of neurodegeneration.

Indexed as

Parkinsonian DisordersSpinocerebellar AtaxiasDopamineHumansPositron-Emission TomographyRacloprideDopamineRacloprideD2 receptor PETFDOPA PETParkinsonismSpinocerebellar ataxia type 6 (SCA6)

Identifiers

PMID32440919
OpenAlexW3028130280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.