ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021
Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The Historical Burden of Sporotrichosis in Brazil: a Systematic Review of Cases Reported from 1907 to 2020.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Pooled it
- Antimicrobial peptides from arthropod venoms exhibit activity againstThe journal of venomous animals and toxins including tropical diseases · 2026Article
- Response to Oxidative Stress inJournal of fungi (Basel, Switzerland) · 2025Review
- In Vitro Evidence for the Efficacy of Manuka Honey and Its Components Against the Major Human PathogenicPharmaceuticals (Basel, Switzerland) · 2025Article
- Sporotrichosis: an overview of the neglected disease reported worldwide in the last five years.Revista da Sociedade Brasileira de Medicina Tropical · 2025Review
- Fungal primary and opportunistic pathogens: an ecological perspective.FEMS microbiology reviews · 2024Review
- In vitro activity of the anthelmintic drug niclosamide against Sporothrix spp. strains with distinct genetic and antifungal susceptibility backgrounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Metabolic Plasticity and Virulence-Associated Factors ofJournal of fungi (Basel, Switzerland) · 2023Article
- Relationship of Sporotrichosis and Infected Patients with HIV-AIDS: An Actual Systematic Review.Journal of fungi (Basel, Switzerland) · 2023Review
- A neglected disease. Human sporotrichosis in a densely populated urban area in São Paulo, Brazil: clinical-epidemiological and therapeutic aspects.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Sporotrichosis Caused by Non-Wild TypeFrontiers in cellular and infection microbiology · 2022Article
- The Consequences of Our Changing Environment on Life Threatening and Debilitating Fungal Diseases in Humans.Journal of fungi (Basel, Switzerland) · 2021Review
- Special issue on sporotrichosis: challenges to deal with the new emerging pathogenic species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
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11 authors at 1 institution in 1 country.
Funding
Abstract
Sporotrichosis in immunocompromised patients has a high morbidity and may cause deaths. Particularly, patients with acquired immunodeficiency syndrome (AIDS) with low T CD4 counts develop a chronic disease, with severe and widespread forms. Recently, the ability of Sporothrix brasiliensis, the main agent of zoonotic sporotrichosis, to increase its virulence in a diabetic patient without HIV infection was described. Since it was a unique finding, it is not known how often this occurs in patients with chronic and refractory sporotrichosis. The aim of this study is to compare sequential Sporothrix isolates obtained from patients with sporotrichosis and AIDS in order to detect changes in virulence-related phenotypes and acquisition of antifungal resistance during the evolution of the disease. Fungal growth in different substrates, antifungal susceptibility, thermotolerance, resistance to oxidative stress, and production of hydrolytic enzymes were evaluated. Correlations were assessed between clinical and phenotypic variables. Sixteen isolates, all identified as S. brasiliensis, obtained from five patients were studied. They grew well on glucose and N-acetyl-D-glucosamine, but poorly on lactate. Except from isolates collected from two patients, which were non-wild type for terbinafine, they were considered wild type for the antifungal drugs tested. Thermotolerance of the isolates was moderate to high. Except for phytase and phospholipase, isolates were able to produce virulence-related enzymes on different levels. Changes in all studied phenotypes were observed during the course of the disease in some patients. The results show that the HIV-driven immunosuppression is more relevant than fungal phenotypes on the unfavorable outcomes of disseminated sporotrichosis.
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