ArticleInternational journal of biometeorology2020
Effects of high-temperature heat wave and ozone on hypertensive rats.
Article in International journal of biometeorology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Extreme Weather Events, Air Pollution, and Cardiovascular Health: Mechanisms and Challenges.Reviews in cardiovascular medicine · 2026Review
- Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States.Circulation · 2025Article
- Interaction effects of high temperature and ozone on cardiovascular disease mortality in Chengdu, 2014-2023.Frontiers in public health · 2025Article
- Adverse short-term effects of ozone on cardiovascular mortalities modified by season and temperature: a time-series study.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the effects of heat waves and ozone on hypertensive rats. Heat wave and ozone pollution were simulated on the Shanghai Meteorological and Environmental Animal Exposure System. Eighteen hypertensive rats were randomly divided into a control group, an ozone group, and a heat wave plus ozone group. The experimental groups were transferred to the exposure system for exposure to the ozone and heat wave plus ozone. After exposure, blood samples were collected from the abdominal aorta, and the hearts were harvested in all groups. The concentrations of inflammatory factors, vasomotion factors, cardiovascular risk factors, oxidative stress and thrombosis factors and heat stress factors in heart tissue were measured in each rat. Ozone exposure and heat wave plus ozone exposure increased the levels of inflammatory factors, thrombosis factors, vasomotion factors and cardiovascular risk factors, except for HDL-C, which was reduced. Moreover, experimental exposure increased the heat stress factors and oxidative stress, except for SOD, which was decreased. These data demonstrated that both ozone exposure and heat wave plus ozone exposure could adversely affect hypertensive rats, and that heat wave may enhance the toxic effect of ozone exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.