Evidence map›Paper›PMID 32440820›Full record

ArticlePurinergic signalling2020

Adenosine receptors regulate exosome production.

Nils Ludwig, Juliana H Azambuja, Aparna Rao, Delbert G Gillespie, Edwin K Jackson, Theresa L Whiteside

Open access · greenAbstract read
In one paragraph

Article in Purinergic signalling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Exosomes: Small EVs with Large Immunomodulatory Effect in Glioblastoma.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nils LudwigDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID 0000-0001-5561-2184
Juliana H AzambujaDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Aparna RaoUPMC Hillman Cancer Center, UPCI Research Pavilion, Suite 1.27, 5117 Centre Avenue, Pittsburgh, PA, 15213, USA.
Delbert G GillespieDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Theresa L WhitesideDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. whitesidetl@upmc.edu.
University of Pittsburgh · USUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUPMC Hillman Cancer Center · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of Renal Dipeptidyl Peptidase IVR01HL069846 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2003 to 2020
$6.6M
The Guanosine-Adenosine MechanismR01HL109002 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2012 to 2023
$5.1M
The Renal 2',3'-cAMP-Adenosine PathwayR01DK068575 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2005 to 2016
$4.0M
Adenosine in Renal Sympathetic NeurotransmissionR01DK091190 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2011 to 2020
$3.4M
NHLBI NIH HHS R01 HL069846NHLBI NIH HHS R01 HL109002NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK068575NIDDK NIH HHS R01 DK091190NIH HHS HL109002, DK091190, HL069846, DK068575, and DK079307NIH HHS R01-CA 1686288
6 · The paper itself

Abstract

Exosomes, small-sized extracellular vesicles, carry components of the purinergic pathway. The production by cells of exosomes carrying this pathway remains poorly understood. Here, we asked whether type 1, 2A, or 2B adenosine receptors (A

Indexed as

AdenosineAdenosine A2 Receptor AgonistsAnimalsExosomesMalePhenethylaminesRatsReceptor, Adenosine A1Receptor, Adenosine A2ATumor Cells, Cultured2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineAdenosineAdenosine A2 Receptor AgonistsPhenethylaminesReceptor, Adenosine A1Receptor, Adenosine A2AAdenosineAdenosine receptorsExosomesExtracellular vesicles

Identifiers

PMID32440820
PMCPMC7367962
OpenAlexW3027620638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.