ArticleEuropean radiology2020
Computed tomography findings of early-stage TAFRO syndrome and associated adrenal abnormalities.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Clinical Images: Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly syndrome presenting as bilateral adrenal hemorrhage.ACR open rheumatology · 2026Article
- Primary adrenal insufficiency and autoimmune thyroiditis in an adolescent with Castleman-TAFRO syndrome.JCEM case reports · 2026Article
- TAFRO Syndrome with Massive Bilateral Adrenal Hemorrhage.Internal medicine (Tokyo, Japan) · 2025Article
- Advances in multimodal imaging for adrenal gland disorders: integrating CT, MRI, and nuclear medicine.Japanese journal of radiology · 2025Review
- Article
- Morphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease.Frontiers in immunology · 2025Article
- TAFRO subtype of idiopathic multicentric Castleman disease in a 22-year-old man.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Article
- TAFRO syndrome with abdominal pain as the first symptom accompanied by liver damage with hyperbilirubinemia: A case report.Heliyon · 2024Article
- Article
- TAFRO Syndrome onDiagnostics (Basel, Switzerland) · 2024Article
- Radiological Imaging Findings of Adrenal Abnormalities in TAFRO Syndrome: A Systematic Review.Biomedicines · 2024Review
- Unexpected diagnosis of rare mesenteric Castleman disease: A case report and literature review.Rare tumors · 2024Article
- Computed tomography findings of idiopathic multicentric Castleman disease subtypes.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Evaluation of the correlation between multiple organ calcification on CT and disease severity in patients with TAFRO syndrome.Japanese journal of radiology · 2023Article
- Acute Abdomen and Adrenal Swelling as the First Manifestations of TAFRO Syndrome.Internal medicine (Tokyo, Japan) · 2023Article
- Thrombocytopenia, anasarca, and severe inflammation.American journal of hematology · 2022Article
- Bilateral Adrenal Infarctions as an Initial Manifestation of TAFRO Syndrome: A Case Report and Review of the Literature.Internal medicine (Tokyo, Japan) · 2022Review
- Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease.American journal of hematology · 2021Article
- Fatal case of TAFRO syndrome with unilateral adrenal hemorrhage in early-stage disease.Journal of clinical and experimental hematopathology : JCEH · 2021Article
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Authors and funding
18 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare CT findings of early (within 3 weeks post-onset)- and later (within 1 month before or after diagnostic criteria were satisfied, and later than 3 weeks post-onset) stage thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome.
methodsBetween 2014 and 2019, 13 patients with TAFRO syndrome (8 men and 5 women; mean age, 54.9 years) from nine hospitals were enrolled. The number of the following CT findings (CT factors) was recorded: the presence of anasarca, organomegaly, adrenal ischaemia, anterior mediastinal lesion, bony lesion, and lymphadenopathy. Records of adrenal disorders (adrenomegaly, ischaemia, and haemorrhage) throughout the disease course were also collected. Differences in CT factors at each stage were statistically compared between remission and deceased groups.
resultsPara-aortic oedema and mild lymphadenopathy were observed in all patients, whereas pleural effusion, ascites, and subcutaneous oedema were found in 5/13, 7/13, and 7/13 cases, respectively, at the early stage. CT factors at the early stage were significantly higher in the deceased than in the remission group (mean, 11 vs 6.5; p = 0.04), while they were nonsignificant at the later stage. Adrenal disorders were present in 7/13 cases throughout the course including 6 of adrenomegaly and 4 of ischaemia at the early stage.
conclusionsPara-aortic oedema and mild lymphadenopathy are most common at the early stage. Anasarca, organomegaly, lymphadenopathy, and adrenal disorders on early-stage CT are useful for unfavourable prognosis prediction. Moreover, adrenal disorders are frequent even at the early stage and are useful for early diagnosis of TAFRO syndrome. KEY POINTS: • CT findings facilitate early diagnosis and prognosis prediction in TAFRO syndrome. • Adrenal disorders are frequently observed in TAFRO syndrome. • Adrenal disorders are useful for differential diagnosis of TAFRO syndrome.
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