Evidence map›Paper›PMID 32440746›Full record

ArticleDigestive diseases and sciences2021

Validation of the Expanded Baveno-VI Criteria for Screening Gastroscopy in Asian Patients with Compensated Advanced Chronic Liver Disease.

Pik-Eu Chang, Chee-Kiat Tan, Chang-Chuen Cheah, Weiquan Li, Wan Cheng Chow, Yu-Jun Wong

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Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pik-Eu ChangDepartment of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
Chee-Kiat TanDepartment of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
Chang-Chuen CheahDepartment of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
Weiquan LiDepartment of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore.
Wan Cheng ChowDepartment of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
Yu-Jun WongDepartment of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore. Eugene.wong.y.j@singhealth.com.sg.ORCID http://orcid.org/0000-0002-0727-1183
Singapore General Hospital · SGChangi General Hospital · SGSingHealth · SG

Funding

Singapore Ministry of Health Service Development Funding No. 06/S03
6 · The paper itself

Abstract

backgroundThe expanded Baveno-VI criteria may further reduce the need for screening gastroscopy compared to Baveno-VI criteria.

aimWe sought to validate the performance of these criteria in a cohort of compensated advanced chronic liver disease (cACLD) patients with predominantly hepatitis B infection.

methodsConsecutive cACLD patients from 2006 to 2012 with paired liver stiffness measurements and screening gastroscopy within 1 year were included. The expanded Baveno-VI criteria were applied to evaluate the sensitivity (SS), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) for the presence of high-risk varices (HRV).

resultsAmong 165 cACLD patients included, 17 (10.3%) had HRV. The commonest etiology of cACLD was chronic hepatitis B (36.4%) followed by NAFLD (20.0%). Application of expanded Baveno-VI criteria avoided more screening gastroscopy (43.6%) as compared to the original Baveno-VI criteria (18.8%) without missing more HRV (1 with both criteria). The overall SS, SP, PPV and NPV of the expanded Baveno-VI criteria in predicting HRV were 94.1%, 48.0%, 17.2% and 98.6%, respectively.

conclusionApplication of the expanded Baveno-VI criteria can safely avoid screening gastroscopy in 43.6% of cACLD patients with an excellent ability to exclude HRV.

Indexed as

Asian PeopleAgedCohort StudiesEnd Stage Liver DiseaseFemaleGastroscopyHepatitis B, ChronicHumansMaleMass ScreeningMiddle AgedReproducibility of ResultsRetrospective StudiesEsophageal and gastric varicesGastroscopyHypertension, PortalLiver cirrhosis

Identifiers

PMID32440746
OpenAlexW3028334078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.