Evidence map›Paper›PMID 32440687›Full record

ArticleBioscience reports2020

The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.

Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang, Meijiang Meng, Zhiming Bai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zengshu XingDepartment of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Sailian LiDepartment of Gastroenterology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, Hainan Province, P.R. China.
Zhenxiang LiuDepartment of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Chong ZhangDepartment of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Meijiang MengDepartment of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Zhiming BaiDepartment of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is a kind of male malignant tumor, which has brought tremendous health threat to men. Prostate cancer is difficult to be cured because of high incidence and metastasis rate. Thereby, it is of great urgency to elucidate the underlying molecular mechanism of prostate cancer for the treatment of this cancer. LINC00473 dysregulation has been observed in many cancers. However, the role of LINC00473 was unknown in prostate cancer. In the present study, we discovered that prostate cancer cells presented high expression of LINC00473, and LINC00473 inhibition limited cell proliferation and the expression of proteins in JAK-STAT3 signaling pathway. Additionally, LINC00473 acted as an up-stream factor for miR-195-5p to negatively modulate miR-195-5p expression. Moreover, SEPT2 interacted with miR-195-5p in prostate cancer and SEPT2 expression was positively modulated by LINC00473 and negatively regulated by miR-195-5p. Last, the inhibitory effect of LINC00473 knockdown on cell proliferation and expression of proteins of JAK-STAT3 signaling pathway was restored by SEPT2 overexpression. All in all, LINC00473 contributed to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer, which provided a novel therapeutic tactic for prostate cancer patients.

Indexed as

Cell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansJanus KinasesMaleMicroRNAsProstatic NeoplasmsRNA, Long NoncodingSeptinsSTAT3 Transcription FactorJanus KinasesLINC00473 RNA, humanMicroRNAsMIRN195 microRNA, humanRNA, Long NoncodingSEPTIN2 protein, humanSeptinsSTAT3 protein, humanSTAT3 Transcription FactorJAK-STAT3 signaling pathwayLINC00473miR-195-5pprostate cancerSEPT2

Identifiers

PMID32440687
PMCPMC7494984
OpenAlexW3027997360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.