Evidence map›Paper›PMID 32440638›Full record

ArticleCurrent developments in nutrition2020

Anemia and Micronutrient Status during Pregnancy, and Their Associations with Obstetric and Infant Outcomes among HIV-Infected Ugandan Women Receiving Antiretroviral Therapy.

Julia L Finkelstein, Heather S Herman, Albert Plenty, Saurabh Mehta, Paul Natureeba, Tamara D Clark, Moses R Kamya, Theodore Ruel, Edwin D Charlebois, Deborah Cohan and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00993031 (Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00993031 phase3completednot on this map

Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women

TypeinterventionalSponsorUniversity of California, San FranciscoRan2009 to 2013Enrolled389ConditionsMalaria, HIV InfectionsArmsLopinavir/ritonavir, Efavirenz, Zidovudine, Lamivudine
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Julia L FinkelsteinDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-9512-5559
Heather S HermanDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Albert PlentyCenter for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA.
Saurabh MehtaDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-3788-0665
Paul NatureebaInfectious Diseases Research Collaboration, Kampala, Uganda.
Tamara D ClarkDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Theodore RuelDivision of Infectious Disease, Department of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
Edwin D CharleboisCenter for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA.
Deborah CohanDepartment of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, USA.
Diane HavlirDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Sera L YoungDepartment of Anthropology and Global Health Studies, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-1763-1218
University of California, San Francisco · USCornell University · USInfectious Diseases Research Collaboration · UGNorthwestern University · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
The immunologic consequences of prenatal exposure to malariaP01HD059454 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2008 to 2017
$22.6M
Health Consequences of Food & Nutrition Insecurity for HIV+ Women & Their InfantsK01MH098902 · NIMH · NORTHWESTERN UNIVERSITY · PI YOUNG, SERA LEWISE · 2012 to 2016
$854k
NICHD NIH HHS P01 HD059454NIMH NIH HHS K01 MH098902NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

backgroundWomen living with HIV (WLHIV) are at higher risk of micronutrient deficiencies and adverse health outcomes. There are limited data on the burden or sequelae of micronutrient deficiencies among pregnant WLHIV receiving antiretroviral therapy (ART).

objectivesWe aimed to examine anemia and vitamin B-12, folate, and vitamin D deficiencies, and their associations with obstetric and infant outcomes, among pregnant WLHIV initiating combination antiretroviral therapy (cART) in rural Uganda.

methodsThis was a prospective analysis among pregnant WLHIV (12-28 weeks of gestation) in PROMOTE-Pregnant Women and Infants (PIs), a randomized trial comparing the effects of protease inhibitor (PI)-based ART with those of a non-PI-based ART on placental malaria risk. We conducted a substudy on the burden of anemia [trimester 1/3: hemoglobin (Hb) <11.0 g/dL; trimester 2: Hb <10.5 g/dL;

results26.8% women were anemic, 30.2% were vitamin B-12 insufficient (<221.0 pmol/L), 66.1% were folate insufficient (<13.5 nmol/L), and 65.4% were vitamin D insufficient (<30.0 ng/mL) at enrollment. Anemia during pregnancy was associated with a greater risk of small for gestational age (SGA) (RR: 1.88; 95% CI: 1.28, 2.77;

conclusionsAnemia and micronutrient deficiencies are associated with a variety of adverse obstetric and infant outcomes and are an important public health concern in perinatal WLHIV on cART and their children.This trial was registered at clinicaltrials.gov as NCT00993031.

Indexed as

AIDSanemiafolatemicronutrientpostpartumpregnantsub-Saharan Africavitamin B-12vitamin D

Identifiers

PMID32440638
PMCPMC7229869
OpenAlexW3020519716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.