ArticleChronic stress (Thousand Oaks, Calif.)
Hippocampal Volume in Psychiatric Diagnoses: Should Psychiatry Biomarker Research Account for Comorbidities?
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use.Npj mental health research · 2025Article
- The Association between Dietary Protein Intake and Sources and the Rate of Longitudinal Changes in Brain Structure.Nutrients · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Smaller cornu ammonis (CA3) as a potential risk factor for suicidal behavior in mood disorders.Journal of psychiatric research · 2023Article
- Reward Processing in Psychiatric Inpatients With Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Imaging synaptic density in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Cross-sectional field study comparing hippocampal subfields in patients with post-traumatic stress disorder, major depressive disorder, post-traumatic stress disorder with comorbid major depressive disorder, and adjustment disorder using routine clinical data.Frontiers in psychology · 2023Article
- miR-124-3p target genes identify globus pallidus role in suicide ideation recovery in borderline personality disorder.Npj mental health research · 2023Article
- Hippocampal Resting-State Functional Connectivity Forecasts Individual Posttraumatic Stress Disorder Symptoms: A Data-Driven Approach.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.Translational psychiatry · 2021Article
- Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?Behavioural brain research · 2020Review
- Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans.Chronic stress (Thousand Oaks, Calif.)Article
- Brain Networks Associated With COVID-19 Risk: Data From 3662 Participants.Chronic stress (Thousand Oaks, Calif.)Article
- Habenular molecular targets for depression, impulsivity, and addiction.Expert opinion on therapeutic targetsArticle
- Decreased Brain Ventricular Volume in Psychiatric Inpatients with Serotonin Reuptake Inhibitor Treatment.Chronic stress (Thousand Oaks, Calif.)Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundMany research papers claim that patients with specific psychiatric disorders (major depressive disorder, posttraumatic stress disorder, borderline personality disorder, alcohol use disorder, and others) have smaller hippocampi, but most of those reports compared patients to healthy controls. We hypothesized that if psychiatrically matched controls (psychiatric control, matched for demographics and psychiatric comorbidities) were used, much of the biomarker literature in psychiatric research would not replicate. We used hippocampus and amygdala volume only as examples, as these are very commonly replicated results in psychiatry biomarker research. We propose that psychiatry biomarker research could benefit from using psychiatric controls, as the use of healthy controls results in data that are not disorder-specific.
methodHippocampus/amygdala volumes were compared between major depressive disorder, sex-/age-/race-matched healthy control, and psychiatric control (N = 126/group). Similar comparisons were performed for posttraumatic stress disorder (N = 67), borderline personality disorder (N = 111), and alcohol use disorder (N = 136).
resultsMajor depressive disorder patients had smaller left (p = 8.79 × 10
conclusionWhen psychiatric controls were used, there was no difference in hippocampal or amygdalar volume between any of the diagnoses studied and controls. This strategy (keeping all possible relevant variables matched between experimental groups) has been used to advance science for hundreds of years, and we propose should also be used in biomarker psychiatry research.
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