ReviewChronic stress (Thousand Oaks, Calif.)
Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress.
Review in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Metabolomics in stress-related disorders: a systematic review and bioinformatics analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System.Cannabis and cannabinoid research · 2022Pooled it
- Does trauma-focused psychotherapy change the brain? A systematic review of neural correlates of therapeutic gains in PTSD.European journal of psychotraumatology · 2021Pooled it
- Occupational post-traumatic stress disorder: an updated systematic review.BMC public health · 2020Pooled it
- NeuronaleNeuro · 2026Article
- Trauma Profiles and Cocaine Use Among Formerly Incarcerated Black Men Who Co-Use Opioids and Stimulants.The Journal of black psychology · 2026Article
- Cardiac event-induced PTSD symptoms and continuous heart rate in coronary artery disease patients.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Article
- Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.Journal of neurochemistry · 2026Article
- Fear of COVID-19: A Comparative Study Among University Students in Peru.TheScientificWorldJournal · 2026Article
- Predictors of Postpartum Post-Traumatic Stress Disorder Following Traumatic Birth: The Influence of Lifetime Trauma, Violence, and Coping Strategies-A Prospective Study.Nursing reports (Pavia, Italy) · 2025Article
- Effect of perioperative psychological intervention on recovery in elderly hip fracture patients with comorbid post-traumatic stress disorder.World journal of psychiatry · 2025Article
- Factors influencing the implementation of interventions for symptoms of posttraumatic stress disorder among hospital-based nurses and physicians during the COVID-19 pandemic: a scoping review.BMC health services research · 2025Article
- Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure.Biological psychiatry global open science · 2025Article
- A projection from the medial prefrontal cortex to the lateral septum modulates coping behavior on the shock-probe test.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Telomere Dynamics in Post-Traumatic Stress Disorder: A Critical Synthesis.Biomedicines · 2025Review
- Effect of chronic alcohol exposure and single-prolonged stress on conditioned fear behavior.Behavioural brain research · 2025Article
- Plasticity of human resilience mechanisms.Science advances · 2025Article
- Psychotherapy Research Domain Criteria: functional mechanisms of treatment and a basic theory of the mind.Frontiers in psychiatry · 2025Review
- Cortisol Imbalance and Fear Learning in PTSD: Therapeutic Approaches to Control Abnormal Fear Responses.Current neuropharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition that can develop following a physical, psychological, or sexual trauma. Despite the growing body of literature examining the psychological and biological factors involved in PTSD psychopathology, specific biomarkers that may improve diagnosis and treatment of PTSD have yet to be identified and validated. This challenge may be attributed to the diverse array of symptoms that individuals with the disorder manifest. Examining the interrelated stress and fear systems allows for a more comprehensive study of these symptoms, and through this approach, which aligns with the research domain criteria (RDoC) framework, neural and psychophysiological measures of PTSD have emerged. In this review, we discuss PTSD neurobiology and treatment within the context of fear and stress network interactions and elucidate the advantages of using an RDoC approach to better understand PTSD with fear conditioning and extinction paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.