Evidence map›Paper›PMID 32440564›Full record

ArticleBioengineering & translational medicine2020

Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization.

Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Dipesh Khanal, Sandra Morales, Elizabeth Kutter, Jian Li, Hak-Kim Chan

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Bacteriophages targetingFrontiers in microbiology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Viruses · 2024
    Review
  9. Article
  10. EudragitPharmaceutics · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Prospects of Inhaled Phage Therapy for Combatting Pulmonary Infections.Frontiers in cellular and infection microbiology · 2021
    Review
  20. BioTM buzz (volume 5, issue 2).Bioengineering & translational medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Rachel Yoon Kyung ChangAdvanced Drug Delivery Group, School of Pharmacy The University of Sydney Sydney New South Wales Australia.
Philip Chi Lip KwokAdvanced Drug Delivery Group, School of Pharmacy The University of Sydney Sydney New South Wales Australia.
Dipesh KhanalAdvanced Drug Delivery Group, School of Pharmacy The University of Sydney Sydney New South Wales Australia.
Sandra MoralesPhage Consulting Sydney New South Wales Australia.
Elizabeth KutterThe Evergreen State College Olympia Washington USA.
Jian LiMonash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology Monash University Clayton Victoria Australia.
Hak-Kim ChanAdvanced Drug Delivery Group, School of Pharmacy The University of Sydney Sydney New South Wales Australia.ORCID https://orcid.org/0000-0002-7054-3137
The University of Sydney · AUAustralian Broadcasting Corporation (Australia) · AUDiscovery Institute · USThe Evergreen State College · US

Funding

Harnessing bacteriophages as natural predators to combat the superbugs: a pulmonary drug delivery approachR33AI121627 · NIAID · UNIVERSITY OF SYDNEY · PI CHAN, KIM · 2018 to 2020
$598k
NIAID NIH HHS R33 AI121627
6 · The paper itself

Abstract

Recent heightened interest in inhaled bacteriophage (phage) therapy for combating antibacterial resistance in pulmonary infections has led to the development of phage powder formulations. Although phages have been successfully bioengineered into inhalable powders with preserved bioactivity, the stabilization mechanism is yet unknown. This paper reports the first study investigating the stabilization mechanism for phages in these powders. Proteins and other biologics are known to be preserved in dry state within a glassy sugar matrix at storage temperatures (

Indexed as

bacteriophage (phage) therapyglass transition temperature (Tg)powderstability, inhalation aerosol

Identifiers

PMID32440564
PMCPMC7237144
OpenAlexW3015571265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.