Evidence map›Paper›PMID 32440493›Full record

ReviewJournal of orthopaedic translation2020

Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants.

Shanshan Chen, Peng Wan, Bingchun Zhang, Ke Yang, Yuhai Li

Abstract readReview
In one paragraph

Review in Journal of orthopaedic translation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
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  10. Article
  11. Osteoporosis and osteoarthritis: A translational perspective.Journal of orthopaedic translation · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shanshan ChenInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
Peng WanSchool of Mechanical Engineering, Dongguan University of Technology, Dongguan 523808, China.
Bingchun ZhangInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
Ke YangInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
Yuhai LiSchool of Material, Shenyang Ligong University, Shenyang 110168, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBisphosphonates (BPs) are known as a group of well-established drugs which are clinically used in metabolic bone disorder-related therapies. Recently increasing interests are focused on the application of BPs in the biodegradable Mg-based implants.

methodsIn this study a facile method was applied to fabricate a zoledronate loaded coating on AZ31 Mg alloy in comparison with the previous construction strategies, such as Ca-P chelation with BPs.

resultsThe results showed that the fluoride pretreated coating could provide better corrosion resistance. Zoledronic acid (ZA) was successfully loaded on the surface of Mg alloy detected by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) analysis, and the release profile was quantified with Ultraviolet (UV) detection.

conclusionIt is considered that this construction of ZA coated Mg-based orthopedic implants could be easily and efficiently used in clinic. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: Different from the traditional drug release mode, this paper used the hydrogen bond between drug molecules and drug carriers to not only realise the effective drug release in the early stage of drug release, but also meet the continuous effect of drugs in the later stage, providing a new possibility for clinical application.

Indexed as

BiodegradableDrug loadingMagnesium alloyOrthopaedic implantZoledronate

Identifiers

PMID32440493
PMCPMC7231978

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.