ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 24 citations in OpenAlex.
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- SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.Cell death & disease · 2023Article
- Germline Variants Associated with Nasopharyngeal Carcinoma Predisposition Identified through Whole-Exome Sequencing.Cancers · 2022Article
- Prognostic Biomarkers for Survival in Nasopharyngeal Carcinoma: A Systematic Review of the Literature.Cancers · 2022Review
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- RNAFrontiers in oncology · 2021Review
- Discovering biomarkers of radioresistance in a radiosensitive cancer: a clinical paradox in nasopharyngeal carcinoma.Annals of translational medicine · 2020Article
- Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
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Authors and funding
42 authors at 7 institutions in 3 countries.
Yun-Miao GuoSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.ORCID https://orcid.org/0000-0002-6118-0805
Jie-Rong ChenSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Yan-Chun FengSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Melvin L K ChuaDivision of Radiation Oncology and Division of Medical Sciences National Cancer Centre Singapore Singapore 169610 Singapore.
Yanni ZengSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Edwin Pun HuiDepartment of Clinical Oncology State Key Laboratory of Translational Oncology Prince of Wales Hospital The Chinese University of Hong Kong Shatin, New Territories Hong Kong SAR P. R. China.
Allen K C ChanDepartment of Chemical Pathology Li Ka Shing Institute of Health Sciences State Key Laboratory of Translational Oncology The Chinese University of Hong Kong Shatin, New Territories Hong Kong SAR P. R. China.
Lin-Quan TangSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Lin WangSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Qian CuiGuangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 P. R. China.
Hui-Qiong HanDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 P. R. China.
Chun-Ling LuoSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Guo-Wang LinSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Yan LiangSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Yang LiuSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Zhong-Lian HeSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Yu-Xiang LiuSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Pan-Pan WeiSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Chu-Jun LiuSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Wan PengSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Bo-Wei HanSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Xiao-Yu ZuoSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Enya H W OngDivision of Radiation Oncology and Division of Medical Sciences National Cancer Centre Singapore Singapore 169610 Singapore.
Eugenia L L YeoDivision of Radiation Oncology and Division of Medical Sciences National Cancer Centre Singapore Singapore 169610 Singapore.
Kar Perng LowDivision of Radiation Oncology and Division of Medical Sciences National Cancer Centre Singapore Singapore 169610 Singapore.
Gek San TanTranslational Pathology Centre Department of Molecular Pathology Singapore General Hospital Singapore 169856 Singapore.
Tony K H LimDepartment of Anatomical Pathology Singapore General Hospital Singapore 169856 Singapore.
Jacqueline S G HwangDepartment of Anatomical Pathology Singapore General Hospital Singapore 169856 Singapore.
Bo LiDepartment of Biochemistry and Molecular Biology Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 P. R. China.
Qi-Sheng FengSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Xiaojun XiaSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Yun-Fei XiaSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Josephine KoDepartment of Clinical Oncology University of Hong Kong Pok Fu Lam Hong Kong SAR P. R. China.
Wei DaiDepartment of Clinical Oncology University of Hong Kong Pok Fu Lam Hong Kong SAR P. R. China.
Maria L LungDepartment of Clinical Oncology University of Hong Kong Pok Fu Lam Hong Kong SAR P. R. China.
Anthony T C ChanDepartment of Clinical Oncology State Key Laboratory of Translational Oncology Prince of Wales Hospital The Chinese University of Hong Kong Shatin, New Territories Hong Kong SAR P. R. China.
Dennis Y M LoDepartment of Chemical Pathology Li Ka Shing Institute of Health Sciences State Key Laboratory of Translational Oncology The Chinese University of Hong Kong Shatin, New Territories Hong Kong SAR P. R. China.
Mu-Sheng ZengSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Hai-Qiang MaiSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Jianjun LiuGuangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 P. R. China.
Yi-Xin ZengSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Jin-Xin BeiSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.
Sun Yat-sen University · CNChinese University of Hong Kong · HKDuke-NUS Medical School · SGSingapore General Hospital · SGUniversity of Hong Kong · HKGuangdong Academy of Medical Sciences · CNFirst Affiliated Hospital of Zhengzhou University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germline polymorphisms are linked with differential survival outcomes in cancers but are not well studied in nasopharyngeal carcinoma (NPC). Here, a two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246 173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazard regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (
Indexed as
biomarkerscancer prognosisgermline polymorphismsnasopharyngeal carcinomaRPA1single nucleotide polymorphisms
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