Evidence map›Paper›PMID 32440404›Full record

ArticlePlastic and reconstructive surgery. Global open2020

Global Approaches to the Prevention and Management of Delayed-onset Adverse Reactions with Hyaluronic Acid-based Fillers.

Wolfgang G Philipp-Dormston, Greg J Goodman, Koenraad De Boulle, Arthur Swift, Claudio Delorenzi, Derek Jones, Izolda Heydenrych, Ada Trindade De Almeida, Rami K Batniji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 66 citations in OpenAlex.

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  14. [Injection anatomy-a new discipline in aesthetic medicine].Dermatologie (Heidelberg, Germany) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 6 countries.

Wolfgang G Philipp-DormstonDepartment of Dermatology, Witten/Herdecke University, Witten, Germany.
Greg J GoodmanFaculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Victoria, Australia.
Koenraad De BoulleAalst Dermatology Clinic, Aalst, Belgium.
Arthur SwiftPrivate Practice, Westmount, Quebec, Canada.
Claudio DelorenziPrivate Practice, Kitchener, Ontario, Canada.
Derek JonesSkin Care and Laser Physicians of Beverly Hills, Beverly Hills, Calif.
Izolda HeydenrychCape Town Cosmetic Dermatology Centre, Cape Town, South Africa.
Ada Trindade De AlmeidaClinica de Dermatologia, Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil.
Rami K BatnijiBatniji Facial Plastic Surgery, Newport Beach, Calif.
Canadian Institute of Mining, Metallurgy and Petroleum · CACape Town Science Centre · ZAHospital do Servidor Público Municipal · BRHuntington Society of Canada · CAMonash University · AUOnze Lieve Vrouwziekenhuis Hospital · BEWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed-onset adverse reactions to hyaluronic acid (HA) fillers are uncommon but have received increased attention, particularly with regard to late-onset nodules. Globally, there is a need for comprehensive prevention and management strategies.

methodsExperts with clinical practices in diverse regions of the world and extensive experience in managing complications related to HA fillers convened to propose and evaluate approaches to prevent delayed-onset adverse reactions after HA filler administration and manage late-onset nodules.

resultsThe expert panel agreed to define delayed-onset adverse reactions as those presenting more than 4 weeks posttreatment, with swelling, induration, and nodulation being the most common clinical signs. The panel recommended 5 general key approaches for the prevention of delayed-onset reactions (patient selection, anatomic location of injection/product selection, aseptic technique, injection procedure/filler, and posttreatment care). Strategies recommended for managing late-onset nodules included oral antibiotics, oral steroids, nonsteroidal anti-inflammatory drugs if needed, hyaluronidase for noninflammatory nodules (recognizing the limitations and regional availability of this treatment), intralesional antibiotics, intralesional immunosuppressive drugs such as steroids and fluorouracil, and surgical excision as a last resort. The panel noted that late-onset nodules may vary in both clinical presentation and etiology, making them challenging to address or prevent, and stressed individualized treatment based on clinical presentation. Regional differences in aseptic protocols, antibiotic selection, and steroid formulations were described.

conclusionInsights from global experts on approaches to prevent and manage delayed-onset adverse reactions following HA filler administration, including late-onset nodules, support clinicians worldwide in optimizing patient outcomes and safety.

Identifiers

PMID32440404
PMCPMC7209845
OpenAlexW3022077130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.