ArticleRegenerative biomaterials2019
Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture.
Article in Regenerative biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- High-throughput synthesis of zinc-functionalized bio-ceramics propels the rational design of bone implants.Bioactive materials · 2026Article
- Biodegradable Zinc-Based Alloys for Guided Bone Regeneration Membranes: Feasibility, Current Status, and Future Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials.Journal of nanobiotechnology · 2025Review
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Zinc oxide nanoparticle chelated phosphocreatine-grafted chitosan composite hydrogels for enhancing osteogenesis and angiogenesis in bone regeneration.Frontiers in medicine · 2025Article
- Review
- The Incorporation of Zinc into Hydroxyapatite and Its Influence on the Cellular Response to Biomaterials: A Systematic Review.Journal of functional biomaterials · 2024Review
- Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms.Materials today. Bio · 2024Review
- Hydroxyapatite or Fluorapatite-Which Bioceramic Is Better as a Base for the Production of Bone Scaffold?-A Comprehensive Comparative Study.International journal of molecular sciences · 2023Article
- The Gradual Release of Alendronate for the Treatment of Critical Bone Defects in Osteoporotic and Control Rats.International journal of nanomedicine · 2023Article
- 3D-Printed PCL/Zn scaffolds for bone regeneration with a dose-dependent effect on osteogenesis and osteoclastogenesis.Materials today. Bio · 2022Article
- Regeneration of Bone Defects in a Rabbit Femoral Osteonecrosis Model Using 3D-Printed Poly (Epsilon-Caprolactone)/Nanoparticulate Willemite Composite Scaffolds.International journal of molecular sciences · 2021Article
- Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation.Regenerative biomaterials · 2021Article
- A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model.Regenerative biomaterials · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is an essential trace element required for bone remodelling process, but its role in such process remains to be elucidated. In particular, inconsistent results have been reported on the effect of Zn on osteoclastic responses, and supplement of receptor activator of nuclear factor kappa-B ligand (RANKL) factors has been commonly adopted. Co-culture is a suitable approach to elucidating the role of Zn in bone remodelling process, by better imitating the cellular environment as the presence of osteoblasts plays critical role in modulating osteoclastic functions. In this study, zinc-substituted HA coatings have been deposited using a liquid precursor plasma spraying process at two different concentrations (1, 2 wt.%). The effect of zinc substitution on osteoblastic and osteoclastic differentiation has been studied
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.