ArticleIranian journal of basic medical sciences2020
Investigating the inhibitory effect of miR-34a, miR-449a, miR-1827, and miR-106b on target genes including NOTCH1, c-Myc, and CCND1 in human T cell acute lymphoblastic leukemia clinical samples and cell line.
Article in Iranian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia.Oncology letters · 2024Article
- CircFBXW7 inhibits the tumorigenesis of T-cell acute lymphoblastic leukemia through modulating miR-494-3p/SOX1 axis.Cell death discovery · 2022Article
- A Comprehensive Analysis of the Downregulation ofFrontiers in molecular biosciences · 2021Article
- Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer.Frontiers in oncology · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesmicroRNAs are small non-coding molecules that regulate gene expression in various biological processes. T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy accompanied with genetic aberrations and accounts for 20% of children's and adult's ALL. Notch signaling pathway dysregulation occurs in 60% of T-ALL cases. In the present study, we aimed to determine the relationship between miRNAs and genes involved in Notch signaling pathway. MATERIALS AND
methodsConsidering the role of the pathway and its down-stream genes in proliferation, differentiation, cell cycle, and apoptosis,
resultsQuantitative Real-Time PCR indicated that
conclusionThese miRNAs can be proposed as biomarkers and new therapeutic targets in T-ALL patients who have
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