ArticleJournal of pain research2020
Efficacy and Safety of Percutaneous Ozone Injection Around Gasserian Ganglion for the Treatment of Trigeminal Neuralgia: A Multicenter Retrospective Study.
Article in Journal of pain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Efficacy and safety of a modified ozone-mediated neurolysis in treatment for patients with resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Trial
- Combined High-Voltage Long-Duration Pulsed Radiofrequency and Ozone Therapy in the Treatment of Pudendal Neuralgia: A Retrospective Case Series.Journal of pain research · 2026Article
- Various gases for the treatment of neuropathic pain: mechanisms, current status, and future perspectives.Medical gas research · 2025Review
- Analysis of 37 cases of percutaneous balloon compression for primary trigeminal neuralgia: experience and outcome from a single center.Frontiers in surgery · 2025Article
- Chemogenetic inhibition of trigeminal ganglion neurons attenuates behavioural and neural pain responses in a model of trigeminal neuropathic pain.European journal of pain (London, England) · 2022Article
- Combined high-voltage pulsed radiofrequency and ozone therapyMedical gas researchArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOzone injection around Gasserian ganglion (OIAGG) has been reported to be an effective treatment for trigeminal neuralgia (TN); however, there remain areas for improvement. To overcome one of these limitations, a multicenter examination of application would be extremely helpful.
objectiveThe goal of this report was to assess the efficacy of OIAGG for refractory TN across multiple centers and to explore factors predictive of successful treatment.
designA multicenter, retrospective study.
settingThe study was conducted across 3 pain centers across China. PATIENTS AND
methodsA total of 103 subjects from 3 pain centers were enrolled in the study. An ozone-oxygen mixture gas at a concentration of 30 µg/mL was injected into the area around the Gasserian ganglion performed under C-arm X-ray guidance. Primary outcome measures included a pain assessment using a visual analog scale (VAS) and the Barrow Neurological Institute (BNI) pain intensity scale. Clinical assessment of patients for these outcome measures was performed at pretreatment, post-treatment, 6 months, 1 year and 2 years after the OIAGG.
resultsSuccessful pain relief was defined as a score within BNI grades I-IIIa. The pain relief rates at post-treatment, 6 months, 1 year and 2 years after the procedure were 88.35%, 86.87%, 84.46% and 83.30%, respectively. The VAS at each observation time point was significantly different from the preoperative levels (P<0.05). Logistic regression analysis showed that previous nerve damage had a significant effect on the treatment results. No significant complications or side effects were found during or after treatment.
conclusionThis multicenter research confirms our previous single center results that OIAGG is both effective and safe for patients with TN.
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