ArticleNeuropsychiatric disease and treatment2020
Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study.
Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Pooled it
- Prescribing behavior of antidepressants for depressive disorders: A systematic review.Frontiers in psychiatry · 2022Pooled it
- 2-Phenyl-3-(Phenylselanyl)Benzofuran As a Promising Antidepressant Candidate: Mechanistic Insights Into Nitrergic Modulation and Subchronic Efficacy and Safety Profiling.Molecular neurobiology · 2026Article
- Antidepressant use at the threshold: people prescribed antidepressants around the time of a dementia diagnosis.Age and ageing · 2026Article
- A survey of community pharmacists perspectives on monitoring antidepressant adverse events.British journal of clinical pharmacology · 2026Article
- Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross-Sectional Study.Depression and anxiety · 2026Article
- Increasing Prevalence of Long-Term Antidepressant Use in Australia: A Retrospective Observational Study.Pharmacoepidemiology and drug safety · 2025Observational
- Factors associated with drug-drug interactions involving citalopram in the UK Biobank.BJPsych open · 2025Article
- Clinical Implications of Antidepressants and Associated Risk of Bleeding: A Narrative Review.Current pain and headache reports · 2025Review
- Uncovering antidepressant prescription patterns: a three-year analysis of outpatient trends.BMC psychiatry · 2025Article
- Potential deprescribing indications for antidepressants between 2012 and 2019: repeated cross-sectional analysis in two Scottish health boards.BMC medicine · 2024Article
- Deprescribing of antidepressants: development of indicators of high-risk and overprescribing using the RAND/UCLA Appropriateness Method.BMC medicine · 2024Article
- Use and misuse of psychoactive medicines: a descriptive cross-sectional study in a densely populated region of Portugal.Journal of pharmaceutical policy and practice · 2024Article
- Prevalence, trends, and individual patterns of long-term antidepressant medication use in the adult Swiss general population.European journal of clinical pharmacology · 2023Article
- Medication use in Italian nursing homes: preliminary results from the national monitoring system.Frontiers in pharmacology · 2023Article
- The Italian consensus conference on psychological therapies for anxiety and depressive disorders: findings and recommendations.Epidemiology and psychiatric sciences · 2022Article
- Analysis of Antidepressants Utilization for Patients Visiting Psychiatric Out-Patient Clinic in a Tertiary Care Hospital.Healthcare (Basel, Switzerland) · 2022Article
- Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review.BMJ open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAntidepressant consumption has risen in recent years, driven by longer treatment duration. The objective of this study was to measure the prevalence of antidepressant long-term and chronic use in the Bologna area, Italy, and to identify their main determinants. MATERIALS AND
methodsWe conducted a retrospective claims-based cohort study by using the Bologna Local Health Authority data. A cohort of 18,307 incident users of antidepressant drugs in 2013 was selected, and subjects were followed for three years. A long-term utilization was defined as having at least one prescription claimed during each year of follow-up, while chronic utilization was defined as claiming at least 180 defined daily doses per year. Factors associated with chronic and long-term use were identified by univariate and multivariate logistic regressions.
resultsIn our cohort, 5448 (29.8%) and 1817 (9.9%) subjects were dispensed antidepressants for a long-term course and in a chronically way, respectively. Older age, antidepressant polytherapy, polypharmacy, and being prescribed the first antidepressant by a hospital physician were all factors independently associated with chronic and long-term prescriptions of antidepressant drugs. Results were reported separately for men and women.
conclusionAntidepressant long-term and chronic prescriptions are common in the Bologna area. Because longer treatment should be clinically motivated, these results strongly prompt the need to evaluate the actual relevance, as they may indicate potentially inappropriate prescription patterns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.