Evidence map›Paper›PMID 32439962›Full record

ArticleNature communications2020

Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.

Lina Sun, Amy V Paschall, Dustin R Middleton, Mayumi Ishihara, Ahmet Ozdilek, Paeton L Wantuch, Javid Aceil, Jeremy A Duke, Celia C LaBranche, Michael Tiemeyer and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. CD8Heliyon · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Follicular Helper T (TFrontiers in immunology · 2021
    Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lina SunDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Amy V PaschallDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Dustin R MiddletonDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Mayumi IshiharaComplex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.
Ahmet OzdilekDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Paeton L WantuchDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Javid AceilDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Jeremy A DukeDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Celia C LaBrancheDepartment of Surgery, Duke University, Durham, NC, 27710, USA.
Michael TiemeyerDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Fikri Y AvciDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA. avci@uga.edu.
University of Georgia · USDuke University · US

Funding

TR&D1: Stem Cell and Induced Pluripotent Stem Cell Resources (Pages 116-134)P41GM103490 · NIGMS · UNIVERSITY OF GEORGIA · PI PIERCE, J. MICHAEL · 2012 to 2018
$13.7M
Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII PathwayR01AI123383 · NIAID · UNIVERSITY OF GEORGIA · PI Fikri Y Avci · 2016 to 2026
$4.2M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
NIAID NIH HHS R01 AI123383NIGMS NIH HHS P41 GM103490NIGMS NIH HHS T32 GM107004
6 · The paper itself

Abstract

The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1 envelope (Env) glycoprotein. Here, we report that a CD4

Indexed as

Amino Acid SequenceAnimalsAntibodies, NeutralizingCD4-Positive T-LymphocytesCytokinesEpitopes, T-LymphocyteGlycopeptidesHistocompatibility Antigens Class IIHIV-1HIV AntibodiesHIV Envelope Protein gp120Immunity, CellularImmunity, HumoralImmunizationMicePolysaccharidesAntibodies, NeutralizingCytokinesEpitopes, T-LymphocyteGlycopeptidesHistocompatibility Antigens Class IIHIV AntibodiesHIV Envelope Protein gp120Polysaccharides

Identifiers

PMID32439962
PMCPMC7242320
OpenAlexW3027623809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.