ArticleScientific reports2020
Propoxur resistance associated with insensitivity of acetylcholinesterase (AChE) in the housefly, Musca domestica (Diptera: Muscidae).
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 32 citations in OpenAlex.
- The P450-Monooxygenase Activity and CYP6D1 Expression in the Chlorfenapyr-Resistant Strain ofInsects · 2024Article
- Lack of fitness costs associated with resistance to permethrin in Musca domestica.Scientific reports · 2024Article
- Single and Combined Mutations of Acetylcholinesterase Gene Giving Resistance to Pirimiphos-Methyl inInsects · 2023Article
- Article
- Time of Day-Specific Changes in Metabolic Detoxification and Insecticide Tolerance in the House Fly,Frontiers in physiology · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two unique housefly strains, PSS and N-PRS (near-isogenic line with the PSS), were used to clarify the mechanisms associated with propoxur resistance in the housefly, Musca domestica. The propoxur-selected resistant (N-PRS) strain exhibited >1035-fold resistance to propoxur and 1.70-, 12.06-, 4.28-, 57.76-, and 57.54-fold cross-resistance to beta-cypermethrin, deltamethrin, bifenthrin, phoxim, and azamethiphos, respectively, compared to the susceptible (PSS) strain. We purified acetylcholinesterase (AChE) from the N-PRS and PSS strains using a procainamide affinity column and characterized the AChE. The sensitivity of AChE to propoxur based on the bimolecular rate constant (K
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