ArticleNature communications2020
Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Comparison of Respiratory Microbiomes in Influenza Versus Other Respiratory Infections: Systematic Review and Analysis.International journal of molecular sciences · 2025Pooled it
- Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease.BMC biology · 2024Pooled it
- The human microbiome and COVID-19: A systematic review.PloS one · 2021Pooled it
- Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24-59 months in The Gambia: a phase 4, open-label, randomised controlled trial.The Lancet. Microbe · 2025Trial
- Paired versus Single Housing of Ferrets (Mustela putorius furo) Does Not Influence Experimental Outcomes of Influenza A Virus Pathogenesis Studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis.Science advances · 2026Article
- Current insights into bacterial secondary infection following influenza A virus infection.Frontiers in microbiology · 2026Review
- Establishment and validation of a ferret model for systemic antibiotic treatment during influenza A virus infection.Lab animal · 2025Article
- Post-viral lung diseases: the microbiota as a key player.ERJ open research · 2025Review
- Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis.Open biology · 2025Review
- The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children.Communications biology · 2025Article
- Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases.Biomedicines · 2025Review
- Cigarette smoke-induced disordered microbiota aggravates the severity of influenza A virus infection.mSystems · 2024Article
- Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome.Genome biology · 2024Article
- Machine learning approaches for influenza A virus risk assessment identifies predictive correlates using ferret model in vivo data.Communications biology · 2024Article
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- Exploring the complexities of poultry respiratory microbiota: colonization, composition, and impact on health.Animal microbiome · 2024Review
- Human nasal microbiota shifts in healthy and chronic respiratory disease conditions.BMC microbiology · 2024Article
- Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair.International journal of molecular sciences · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
Abstract
Infection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are largely unknown. Here, we report a longitudinal study to assess the temporal dynamics of the URT microbiomes of uninfected and influenza virus-infected humans and ferrets. Uninfected human patients and ferret URT microbiomes have stable healthy ecostate communities both within and between individuals. In contrast, infected patients and ferrets exhibit large changes in bacterial community composition over time and between individuals. The unhealthy ecostates of infected individuals progress towards the healthy ecostate, coinciding with viral clearance and recovery. Pseudomonadales associate statistically with the disturbed microbiomes of infected individuals. The dynamic and resilient microbiome during influenza virus infection in multiple hosts provides a compelling rationale for the maintenance of the microbiome homeostasis as a potential therapeutic target to prevent IAV associated bacterial co-infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.