Evidence map›Paper›PMID 32439900›Full record

SynthesisNature communications2020

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R Tucker, Seung Hoan Choi, Mark D Chaffin, Carolina Roselli, Michael R Barnes and 177 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 9 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 9 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Article
  12. Wavelet Decomposition-Based Genomic Analysis of the Human Electrocardiogram.medRxiv : the preprint server for health sciences · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026
    Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

187 authors at 20 institutions in 16 countries.

Ioanna Ntalla *William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lu-Chen Weng *Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1475-4930
James H CartwrightWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Amelia Weber HallCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7915-0313
Gardar SveinbjornssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Nathan R TuckerCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5071-4218
Seung Hoan ChoiProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mark D ChaffinProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1234-5562
Carolina RoselliProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5267-6756
Michael R BarnesWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9097-7381
Borbala MifsudWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-3429-3094
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
James J CranleyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Maria Pina ConcasInstitute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.ORCID http://orcid.org/0000-0003-3598-2537
Paolo GaspariniInstitute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Thibaud BoutinMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4754-1675
Ivana KolcicUniversity of Split School of Medicine, Split, Croatia.ORCID http://orcid.org/0000-0001-7918-6052
Ozren PolasekUniversity of Split School of Medicine, Split, Croatia.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6993-6884
Nathalia M AraujoDepartamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Maria Fernanda Lima-CostaRene Rachou Reserch Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
Antonio Luiz P RibeiroHospital das Clínicas e Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Renan P SouzaDepartamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0002-9479-4432
Eduardo Tarazona-SantosDepartamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Vilmantas GiedraitisDepartment of Public Health, Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2256-6972
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Andrew P MorrisWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6805-6014
Fabiola Del Greco MInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Luisa FocoInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Martin GögeleInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Andrew A HicksInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.ORCID http://orcid.org/0000-0001-6320-0411
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Lars LindMedical Sciences, Uppsala University Hospital, Uppsala, Sweden.
Cecilia M LindgrenNuffield Department of Medicine, Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK.
Johan SundströmDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2247-8454
Christopher P NelsonDepartment of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0001-8025-2897
Muhammad B RiazDepartment of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-5512-1745
Nilesh J SamaniDepartment of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.
Gianfranco SinagraCardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0003-2700-8478
Sheila UliviInstitute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Pashupati P MishraDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0001-5177-3431
Nina MononenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Kjell NikusDepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Mark J CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9295-3594
Anna DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-4913-3608
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
May E MontasserDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeff R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Kathleen RyanDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Alan R ShuldinerDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Stefanie AeschbacherCardiology Division, University Hospital, Basel, Switzerland.
David ConenCardiology Division, University Hospital, Basel, Switzerland.
Lorenz RischInstitute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-2692-6699
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Catriona L K BarnesCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Peter K JoshiCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
James F WilsonMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Aaron IsaacsCARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department of Biochemistry, and Department of Physiology, Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-5037-4834
Jan A KorsDepartment of Medical Informatics Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Paul L HuangCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Girish N NadkarniThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5266-8465
Adolfo CorreaJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.ORCID http://orcid.org/0000-0002-9501-600X
Hao MeiDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
James WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Thomas MeitingerDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Martina Müller-NurasyidDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.ORCID http://orcid.org/0000-0003-3793-5910
Annette PetersDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.ORCID http://orcid.org/0000-0003-0583-5093
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0002-2167-7470
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-2581-070X
Yordi J van de VegteDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-4303-7685
Stefan KääbDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Katharina SchrammDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Moritz F SinnerDZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Michael J CutlerIntermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.
Diane FatkinMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.ORCID http://orcid.org/0000-0002-9010-9856
Barry LondonDepartment of Cardiovascular Medicine, University of Iowa, Iowa City, IA, USA.
Morten OlesenLaboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.
Dan M RodenDepartments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
M Benjamin ShoemakerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University and Skane University Hospital, Lund, Sweden.
Mary L BiggsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3071-7278
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Alessandro De GrandiInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Christian FuchsbergerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Cristian PattaroInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.ORCID http://orcid.org/0000-0002-4119-0109
Peter P PramstallerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Peter W MacfarlaneInstitute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Stella TrompetDepartment of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Marcus DörrDZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Stephan B FelixDZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Uwe VölkerDZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Stefan WeissDZHK (German Centre for Cardiovascular Research), Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Aki S HavulinnaFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4787-8959
Antti JulaFinnish Institute for Health and Welfare, Helsinki, Finland.
Katri SääksjärviFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5061-4911
Veikko SalomaaFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Xiuqing GuoInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Susan R HeckbertCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
Henry J LinInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Kent D TaylorInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-2756-4370
Jie YaoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Arie C MaanDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Raymond NoordamDepartment of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Francesco CuccaDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Jun DingLaboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.
Edward G LakattaLaboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4772-0035
Yong QianLaboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.
Kirill V TarasovLaboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA.
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Honghuang LinNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
Christopher H Newton-ChehProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kathryn L LunettaNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-9268-810X
Alison D MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.ORCID http://orcid.org/0000-0003-4915-4847
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-5362-9430
Bruno H StrickerDepartment of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
André UitterlindenHuman Genotyping Facility Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Marten E van den BergDepartment of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jeffrey HaesslerFred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USA.
Charles KooperbergFred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Ulrike PetersFred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5666-9318
Alexander P ReinerFred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Eric A WhitselDepartments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2225-8323
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Georg B EhretCardiology, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-5730-0675
Elsayed Z SolimanEpidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-5632-8150
Christy L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7231-9745
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6438-9583
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Amanda A SeyerleDivision of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USA.
Adrienne StilpDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Solmaz AssaDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M Abdullah SaidDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-2920-7745
M Yldau van der EndeDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pier D LambiaseBarts Heart Centre, St Bartholomews Hospital, London, UK.
Michele OriniBarts Heart Centre, St Bartholomews Hospital, London, UK.ORCID http://orcid.org/0000-0001-5773-0344
Julia RamirezWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-4130-5866
Stefan Van DuijvenbodenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-8897-558X
David O ArnardeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Daniel F GudbjartssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Hilma HolmdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Patrick SulemdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7123-6123
Gudmar ThorleifssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Rosa B ThorolfsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7475-0398
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Emelia J BenjaminNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0003-4076-2336
Andrew TinkerWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Kari StefanssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Patrick T EllinorCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Yalda JamshidiGenetics Research Centre, Molecular and Clinical Sciences Institute, St George's, University of London, London, UK.ORCID http://orcid.org/0000-0003-0151-6482
Steven A LubitzCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-9599-4866
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.ORCID http://orcid.org/0000-0002-4176-2947
Queen Mary University of London · GBUniversity of Washington · USBroad Institute · USdeCODE Genetics (Iceland) · ISEurac Research · ITUniversity Medical Center Groningen · NLLeiden University Medical Center · NLErasmus MC · NLHelmholtz Zentrum München · DEBoston University · USJackson Memorial Hospital · USTampere University of Applied Sciences · FIThe Lundquist Institute · USUniversitätsmedizin Greifswald · DEUniversity of Edinburgh · GBUniversity of Glasgow · GBUniversity of Maryland, Baltimore · USFinnish Institute for Health and Welfare · FIFred Hutch Cancer Center · USIcahn School of Medicine at Mount Sinai · US

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
From gene regions to whole chromosomes: scaling up association-finding for disease and omics outcomes in TOPMedU01HL137162 · NHLBI · UNIVERSITY OF WASHINGTON · PI RICE, KENNETH M. · 2017 to 2019
$1.6M
Defining the functional variation underlying atrial fibrillation riskK01HL140187 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TUCKER, NATHAN R · 2018 to 2022
$858k
Mentoring in patient-oriented atrial fibrillation and cardiovascular researchK24HL148521 · NHLBI · EMORY UNIVERSITY · PI ALONSO, ALVARO · 2019 to 2023
$593k
British Heart Foundation PG/17/59/33139British Heart Foundation PG/20/18/35058Medical Research Council G9521010Medical Research Council MC_UU_00007/10Medical Research Council MR/N025083/1NHLBI NIH HHS K01 HL140187NHLBI NIH HHS K24 HL148521NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL139731NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01 HL137162NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.

Indexed as

ElectrocardiographyArrhythmias, CardiacCardiovascular DiseasesEndophenotypesFemaleGene ExpressionGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMultifactorial InheritanceQuantitative Trait Loci

Identifiers

PMID32439900
PMCPMC7242331
OpenAlexW3028232944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.