ArticleCommunications biology2020
A virophage cross-species infection through mutant selection represses giant virus propagation, promoting host cell survival.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Pantanal virophage: a new virophage species associated with a moumouvirus and a transpoviron, expanding the genusJournal of virology · 2026Article
- Sputnik virophage disrupts the transcriptional regulation of its host giant virus.Journal of virology · 2025Article
- Endogenous virophages are active and mitigate giant virus infection in the marine protistProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Widespread occurrence and diverse origins of polintoviruses influence lineage-specific genome dynamics in stony corals.Virus evolution · 2024Article
- Article
- Epigenetic influences of mobile genetic elements on ciliate genome architecture and evolution.The Journal of eukaryotic microbiology · 2022Review
- Isolation and Identification of a Large Green Alga Virus (Journal of virology · 2022Article
- Integrated viral elements suggest the dual lifestyle ofVirus evolution · 2022Article
- Morphological and Taxonomic Properties of the Newly IsolatedJournal of virology · 2021Article
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus adaptation to new hosts is a major cause of infectious disease emergence. This mechanism has been intensively studied in the context of zoonotic virus spillover, due to its impact on global health. However, it remains unclear for virophages, parasites of giant viruses and potential regulators of microbial communities. Here, we present, for the first time to our knowledge, evidence of cross-species infection of a virophage. We demonstrated that challenging the native population of Guarani virophage with two previously unidentified giant viruses, previously nonpermissive to this virophage, allows the selection of a mutant genotype able to infect these giant viruses. We were able to characterize the potential genetic determinant (deletion) carried by the virophage with the expanded-host range. Our study also highlights the relevant biological impact of this host adaptation by demonstrating that coinfection with the mixture containing the mutant virophage abolishes giant virus production and rescues the host cell population from lysis.
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