Evidence map›Paper›PMID 32439845›Full record

ArticleMolecular psychiatry2021

In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study.

Masamichi Yokokura, Kiyokazu Takebasashi, Akiyo Takao, Kyoko Nakaizumi, Etsuji Yoshikawa, Masami Futatsubashi, Katsuaki Suzuki, Kazuhiko Nakamura, Hidenori Yamasue, Yasuomi Ouchi

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

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  11. Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Masamichi YokokuraDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kiyokazu TakebasashiDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Akiyo TakaoYamaguchi University, Yamaguchi, Japan.
Kyoko NakaizumiDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Etsuji YoshikawaCentral Research Laboratory, Hamamatsu Photonics K.K, Hamamatsu, Japan.
Masami FutatsubashiGlobal Strategic Challenge Center, Hamamatsu Photonics K.K, Hamamatsu, Japan.
Katsuaki SuzukiDepartment of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kazuhiko NakamuraDepartment of Neuropsychiatry, Hirosaki University, Hirosaki, Japan.
Hidenori YamasueDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yasuomi OuchiDepartment of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu, Japan. ouchi@hama-med.ac.jp.ORCID http://orcid.org/0000-0002-1795-0614
Hamamatsu University School of Medicine · JPHamamatsu Photonics (Japan) · JPHamamatsu University · JPHirosaki University · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in the cortical dopamine system and microglial activation have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), one of neurodevelopmental disorders that can be conventionally treated with a dopamine enhancer (methylphenidate) albeit unsatisfactorily. Here, we investigated the contributions of the dopamine D1 receptor (D1R) and activated microglia and their interactions to the clinical severities in ADHD individuals using positron emission tomography (PET). Twenty-four psychotropic-naïve ADHD individuals and 24 age- and sex-matched typically developing (TD) subjects underwent PET measurements with [

Indexed as

Attention Deficit Disorder with HyperactivityDorsolateral Prefrontal CortexHumansMagnetic Resonance ImagingMicrogliaPositron-Emission TomographyPrefrontal CortexReceptors, Dopamine D1Receptors, Dopamine D1

Identifiers

PMID32439845
OpenAlexW3026619959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.