Evidence map›Paper›PMID 32439821›Full record

ArticleNeurology2020

Generalized myoclonus in COVID-19.

Pablo Rábano-Suárez, Laura Bermejo-Guerrero, Antonio Méndez-Guerrero, Javier Parra-Serrano, Daniel Toledo-Alfocea, Daniel Sánchez-Tejerina, Teresa Santos-Fernández, María Dolores Folgueira-López, Judit Gutiérrez-Gutiérrez, Blanca Ayuso-García and 2 more

Registry-linked trialOpen access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04632719 (MentalPlus® for Assessment and Rehabilitation of Cognitive Functions After Remission of Symptoms of COVID-19), which is not on this map. Cited by 86 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 6 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04632719 nacompletednot on this map

MentalPlus® for Assessment and Rehabilitation of Cognitive Functions After Remission of Symptoms of COVID-19

TypeinterventionalSponsorUniversity of Sao PauloRan2020 to 2023Enrolled200ConditionsCognitive Impairment, Covid19, Cognitive Dysfunction, Depression, AnxietyArmsThe use of the MentalPlus® digital game for assessment and rehabilitation of cognitive function after remission of the symptoms of COVID-19
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 6 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  6. Pooled it
  7. Review
  8. Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Neurologic and Neuromuscular Sequelae of COVID-19.Physical medicine and rehabilitation clinics of North America · 2023
    Review
  14. Movement Disorders and SARS-CoV-2.Movement disorders clinical practice · 2023
    Article
  15. Article
  16. Opsoclonus Myoclonus Ataxia Syndrome Due to SARS-CoV-2.Neuro-ophthalmology (Aeolus Press) · 2023
    Review
  17. Article
  18. Article
  19. Myoclonic Encephalopathy Related to SARS-CoV-2 Infection.Movement disorders clinical practice · 2022
    Article
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Pablo Rábano-SuárezFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Laura Bermejo-GuerreroFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Antonio Méndez-GuerreroFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.ORCID 0000-0001-5792-9361
Javier Parra-SerranoFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Daniel Toledo-AlfoceaFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.ORCID 0000-0002-5624-638X
Daniel Sánchez-TejerinaFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Teresa Santos-FernándezFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
María Dolores Folgueira-LópezFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Judit Gutiérrez-GutiérrezFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.ORCID 0000-0001-9046-7306
Blanca Ayuso-GarcíaFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Jesús González de la AlejaFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain.
Julián Benito-LeónFrom the Departments of Neurology (P.R.-S., L.B.-G., A.M.-G., J.P.-S., D.T.-A., D.S.-T., T.S.-F., J.G.d.l.A., J.B.-L.), Microbiology (M.D.F.-L.), Intensive Care Unit (J.G.-G.), and Internal Medicine (B.A.-G.), University Hospital "12 de Octubre"; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L.); and Department of Medicine (M.D.F.-L., J.B.-L.), Universidad Complutense, Madrid, Spain. jbenitol67@gmail.com.
Centro de Investigación Biomédica en Red · ES

Funding

ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORR01NS039422 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2000 to 2013
$7.7M
NINDS NIH HHS R01 NS039422
6 · The paper itself

Abstract

objectiveTo report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus.

methodsPatient data were obtained from medical records from the University Hospital "12 de Octubre," Madrid, Spain.

resultsThree patients (2 men and 1 woman, aged 63-88 years) presented with mild hypersomnia and generalized myoclonus following the onset of the so-called inflammatory phase of coronavirus disease 2019 (COVID-19). All of them had presented previously with anosmia. Myoclonus was generalized with both positive and negative jerks, predominantly involving the facial, trapezius, sternocleidomastoid, and upper extremities muscles. These myoclonic jerks occurred spontaneously and were extremely sensitive to multisensory stimuli (auditive and tactile) or voluntary movements, with an exaggerated startle response. Other causes of myoclonus were ruled out, and none of the patients had undergone respiratory arrest or significant prolonged hypoxia. All of them improved, at least partially, with immunotherapy.

conclusionsOur 3 cases highlight the occurrence of myoclonus during the COVID-19 pandemic as a post- or para-infectious immune-mediated disorder. However, we cannot rule out that SARS-CoV-2 may spread transneuronally to first- and second-order structures connected with the olfactory bulb. Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and optimal treatment.

Indexed as

BetacoronavirusAgedAged, 80 and overCoronavirus InfectionsCOVID-19FemaleGlucocorticoidsHumansMaleMethylprednisoloneMiddle AgedMyoclonusPandemicsPneumonia, ViralSARS-CoV-2GlucocorticoidsMethylprednisolone

Identifiers

PMID32439821
PMCPMC7455360
OpenAlexW3028176165

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.