Evidence map›Paper›PMID 32439816›Full record

ArticlePediatrics2020

SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children.

Francesco Licciardi, Giulia Pruccoli, Marco Denina, Emilia Parodi, Manuela Taglietto, Sergio Rosati, Davide Montin

Abstract readComment
PubMed Publisher
In one paragraph

Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 13 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 13 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Oral manifestations of multisystemic inflammatory syndrome in children (MIS-C) and Kawasaki disease associated to COVID-19: A systematic review.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2022
    Pooled it
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  3. Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
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  7. Guideline
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  11. Kawasaki-like disease in children with COVID-19.Rheumatology international · 2020
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  12. Guideline
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  14. Review
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Francesco LicciardiDepartment of Pediatric and Public Health Sciences, University of Torino, Turin, Italy.
Giulia PruccoliDepartment of Pediatric and Public Health Sciences, University of Torino, Turin, Italy; giu.pruccoli@gmail.com.
Marco DeninaDepartment of Pediatric and Public Health Sciences, University of Torino, Turin, Italy.
Emilia ParodiDepartment of Pediatric and Public Health Sciences, University of Torino, Turin, Italy.
Manuela TagliettoRegina Margherita Children's Hospital, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
Sergio RosatiDepartment of Veterinary Sciences, University of Turin, Turin, Italy; and.
Davide MontinDepartment of Pediatric and Public Health Sciences, University of Torino, Turin, Italy.
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe 2 children with persistent fever and profuse diarrhea who developed signs of mucocutaneous involvement (conjunctivitis, fissured lips, skin rash, erythema, and edema of the hands and feet). Blood tests revealed elevated markers of inflammation, lymphopenia, thrombocytopenia, and complement consumption. Afterward, diffuse edema with hypoalbuminemia appeared in the context of a capillary leak syndrome. In both patients, repeated nasal swabs were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but each patient had high titers of immunoglobulin G and immunoglobulin M against the SARS-CoV-2 virus. The negative PCR results in the presence of immunoglobulin M and immunoglobulin G suggested that the inflammatory response developed in the late phase of viral infection, when SARS-CoV-2 was not detectable in the upper airway. In this report, we describe patients with what we propose to name as SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome. SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome seems to be caused by a delayed response to SARS-CoV-2. It resembles Kawasaki disease complicated by macrophage activation syndrome, although it has peculiar features, such as prodromal diarrhea, capillary leak syndrome, and myocardial dysfunction. Intravenous corticosteroid treatment appears to be helpful.

Indexed as

CoronavirusCoronavirus InfectionsPandemicsPneumonia, ViralBetacoronavirusChildCOVID-19HumansPhenotypeSARS-CoV-2Shock, Cardiogenic

Identifiers

PMID32439816
OpenAlexW3027136438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.