Evidence map›Paper›PMID 32439804›Full record

ArticleThe Journal of biological chemistry2020

Role of the trigger loop in translesion RNA synthesis by bacterial RNA polymerase.

Aleksei Agapov, Artem Ignatov, Matti Turtola, Georgiy Belogurov, Daria Esyunina, Andrey Kulbachinskiy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Aleksei AgapovInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Artem IgnatovInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Matti TurtolaDepartment of Biochemistry, University of Turku, Turku, Finland.ORCID 0000-0003-1694-1027
Georgiy BelogurovDepartment of Biochemistry, University of Turku, Turku, Finland.
Daria EsyuninaInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia akulb@img.ras.ru es_dar@inbox.ru.
Andrey KulbachinskiyInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia akulb@img.ras.ru es_dar@inbox.ru.
Institute of Molecular Genetics · RUUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA lesions can severely compromise transcription and block RNA synthesis by RNA polymerase (RNAP), leading to subsequent recruitment of DNA repair factors to the stalled transcription complex. Recent structural studies have uncovered molecular interactions of several DNA lesions within the transcription elongation complex. However, little is known about the role of key elements of the RNAP active site in translesion transcription. Here, using recombinantly expressed proteins,

Indexed as

Gene Expression Regulation, BacterialTranscription, GeneticDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsRNA, BacterialDNA-Directed RNA PolymerasesEscherichia coli ProteinsRNA, BacterialDksADNA damageDNA repairGreAnucleotide excision repair (NER)RNARNA polymeraseRNA polymerase (RNAP)secondary channel factortranscriptiontranscription-coupled repairtranslesion transcriptiontrigger loop

Identifiers

PMID32439804
PMCPMC7363142
OpenAlexW3027271680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.