Evidence map›Paper›PMID 32439803›Full record

ArticleThe Journal of biological chemistry2020

Hypoxia drives the assembly of the multienzyme purinosome complex.

Cyrielle Doigneaux, Anthony M Pedley, Ishna N Mistry, Monika Papayova, Stephen J Benkovic, Ali Tavassoli

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Research square · 2026
    Article
  3. Coordination of cell organelles to promote metabolon formation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Multiplex mapping of protein-protein interaction interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Multiplex mapping of protein-protein interaction interfaces.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cyrielle DoigneauxSchool of Chemistry, University of Southampton, Southampton, United Kingdom.
Anthony M PedleyDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-1034-5072
Ishna N MistrySchool of Chemistry, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-0275-5792
Monika PapayovaSchool of Chemistry, University of Southampton, Southampton, United Kingdom.
Stephen J BenkovicDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-3680-3481
Ali TavassoliSchool of Chemistry, University of Southampton, Southampton, United Kingdom a.tavassoli@soton.ac.uk.ORCID 0000-0002-7420-5063

Funding

TRANSFORMYLASE ENZYMES--DIHYDROFOLATE REDUCTASER01GM024129 · NIGMS · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BENKOVIC, STEPHEN J · 1985 to 2024
$5.2M
TRANSFORMYLASE ENZYMES/DIHYDROFOLATE REDUCTASER37GM024129 · NIGMS · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BENKOVIC, STEPHEN J · 1987 to 1996
–
Cancer Research UK 20185Cancer Research UK A20185NIGMS NIH HHS R01 GM024129NIGMS NIH HHS R37 GM024129
6 · The paper itself

Abstract

The purinosome is a dynamic metabolic complex composed of enzymes responsible for

Indexed as

Cell HypoxiaHeLa CellsHumansHydroxymethyl and Formyl TransferasesHypoxia-Inducible Factor 1Multienzyme ComplexesNucleotide DeaminasesPurinesHydroxymethyl and Formyl TransferasesHypoxia-Inducible Factor 1inosine monophosphate synthaseMultienzyme ComplexesNucleotide DeaminasesPurines5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC)cell metabolismcellular metabolismde novo purine biosynthesisHIF-1hypoxiahypoxia-inducible factor 1hypoxia-inducible factor (HIF)metabolismmetabolonpurinepurinosome

Identifiers

PMID32439803
PMCPMC7363121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.