Evidence map›Paper›PMID 32439718›Full record

ArticleRNA (New York, N.Y.)2020

Revisiting the window of opportunity for cotranscriptional splicing in budding yeast.

Vahid Aslanzadeh, Jean D Beggs

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vahid AslanzadehWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.ORCID 0000-0002-4500-1627
Jean D BeggsWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.ORCID 0000-0002-8179-6519
Wellcome Centre for Cell Biology · GB

Funding

Wellcome Trust 092076Wellcome Trust 104648
6 · The paper itself

Abstract

We reported previously that, in budding yeast, transcription rate affects both the efficiency and fidelity of pre-mRNA splicing, especially of ribosomal protein transcripts. Here, we report that the majority of ribosomal protein transcripts with non-consensus 5' splice sites are spliced less efficiently when transcription is faster, and more efficiently with slower transcription. These results support the "window of opportunity" model, and we suggest a possible mechanism to explain these findings.

Indexed as

RibosomesRNA PrecursorsRNA SplicingSaccharomycetalesTranscription, GeneticRNA PrecursorsintronsRNA polymeraseRNA polymerase speedyeast

Identifiers

PMID32439718
PMCPMC7430680
OpenAlexW3027463916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.