ArticleeNeuro
Distinct Region- and Time-Dependent Functional Cortical Adaptations in C57BL/6J Mice after Short and Prolonged Alcohol Drinking.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol.Neuropharmacology · 2026Article
- Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.Alcohol, clinical & experimental research · 2025Article
- Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation.iScience · 2025Article
- KAlcohol (Fayetteville, N.Y.) · 2025Article
- Effects of chronic ethanol exposure on dorsal medial striatal neurons receiving convergent inputs from the orbitofrontal cortex and basolateral amygdala.Neuropharmacology · 2025Article
- Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025Review
- Proactive Versus Reactive Control Strategies Differentially Mediate Alcohol Drinking in Male Wistars and P Rats.eNeuro · 2024Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.Neuropharmacology · 2024Article
- Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.Translational psychiatry · 2023Article
- Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.Molecular psychiatry · 2023Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.bioRxiv : the preprint server for biology · 2023Article
- Article
- Adolescence alcohol exposure impairs fear extinction and alters medial prefrontal cortex plasticity.Neuropharmacology · 2022Article
- Orbitofrontal cortex subregion inhibition during binge-like and aversion-resistant alcohol drinking.Alcohol (Fayetteville, N.Y.) · 2022Article
- Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder.Frontiers in synaptic neuroscience · 2022Review
- Understanding ethanol's acute effects on medial prefrontal cortex neural activity using state-space approaches.Neuropharmacology · 2021Review
- Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior.Neuropharmacology · 2021Review
- Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: A neural basis for its disinhibitory effect?Neuropharmacology · 2021Article
- Increased Synaptic Strength and mGluAlcoholism, clinical and experimental research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol (ethanol) use disorder is associated with changes in frontal cortical areas including the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) that contribute to cognitive deficits, uncontrolled drinking, and relapse. Acute ethanol exposure reduces intrinsic excitability of lateral OFC (lOFC) neurons, while chronic exposure and long-term drinking influence plasticity of intrinsic excitability and function of glutamatergic synapses. However, the time course that these adaptations occur across a history of ethanol drinking is unknown. The current study examined whether short-term and long-term voluntary ethanol consumption using an intermittent access paradigm would alter the biophysical properties of deep-layer pyramidal neurons in the ACC and lOFC. Neuronal spiking varied in the ACC with an initial increase in evoked firing after 1 d of drinking followed by a decrease in firing in mice that consumed ethanol for one week. No difference in lOFC spike number was observed between water controls and 1-d ethanol drinking mice, but mice that consumed ethanol for one week or more showed a significant increase in evoked firing. Voluntary ethanol drinking for 4 weeks also produced a total loss of ethanol inhibition of lOFC neurons. There was no effect of drinking on excitatory or inhibitory synaptic events in ACC or lOFC neurons across all time points in this model. Overall, these results demonstrate that voluntary drinking alters neuronal excitability in the ACC and lOFC in distinct ways and on a different time scale that may contribute to the impairment of prefrontal cortex-dependent behaviors observed in individuals with alcohol use disorder (AUD).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.