Evidence map›Paper›PMID 32439712›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2020

Oligodendrocyte ARNT2 expression is altered in models of MS.

Pierre Becquart, Jake Johnston, Carles Vilariño-Güell, Jacqueline A Quandt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Aryl hydrocarbon receptor nuclear translocator 2: a forgotten per-ARNT-Sim transcription factor.Toxicological sciences : an official journal of the Society of Toxicology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pierre BecquartFrom the Department of Pathology and Laboratory Medicine (P.B., J.J., J.A.Q.), University of British Columbia, Vancouver, BC, Canada; and Department of Medical Genetics (C.V.-G.), University of British Columbia, Vancouver, BC, Canada.
Jake JohnstonFrom the Department of Pathology and Laboratory Medicine (P.B., J.J., J.A.Q.), University of British Columbia, Vancouver, BC, Canada; and Department of Medical Genetics (C.V.-G.), University of British Columbia, Vancouver, BC, Canada.
Carles Vilariño-GüellFrom the Department of Pathology and Laboratory Medicine (P.B., J.J., J.A.Q.), University of British Columbia, Vancouver, BC, Canada; and Department of Medical Genetics (C.V.-G.), University of British Columbia, Vancouver, BC, Canada.
Jacqueline A QuandtFrom the Department of Pathology and Laboratory Medicine (P.B., J.J., J.A.Q.), University of British Columbia, Vancouver, BC, Canada; and Department of Medical Genetics (C.V.-G.), University of British Columbia, Vancouver, BC, Canada. jquandt@pathology.ubc.ca.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe examined expression of aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), a basic-loop-helix transcription factor implicated in neuronal development and axonal health, in oligodendrocyte (OL) cultures and over the course of chronic experimental autoimmune encephalomyelitis (EAE), the murine model of multiple sclerosis (MS).

methodsWe assessed OL ARNT2 expression in EAE compared with sham-immunized controls and also in OL primary cultures and over the course of dibutyryl cyclic adenosine monophosphate (dbcAMP)-mediated maturation of the immortalized Oli-neu cell line. We also tested the functional role of ARNT2 in influencing OL characteristics using small interfering RNA (siRNA).

resultsARNT2 is localized to Olig2

conclusionThe analysis of ARNT2 expression in OLs demonstrates that OL ARNT2 expression is altered in EAE and during OL maturation. Findings point to ARNT2 as an important mediator of OL viability and differentiation and warrant further characterization as a target for intervention in demyelinating disorders such as MS.

Indexed as

AnimalsAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsCell LineCells, CulturedCerebral CortexEmbryo, MammalianEncephalomyelitis, Autoimmune, ExperimentalFemaleMiceMice, Inbred C57BLMultiple SclerosisOligodendrocyte Precursor CellsOligodendrogliaArnt2 protein, mouseAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix Proteins

Identifiers

PMID32439712
PMCPMC7251514
OpenAlexW3028214894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.