Evidence map›Paper›PMID 32439494›Full record

ArticleExperimental cell research2020

Automated cell cluster analysis provides insight into multi-cell-type interactions between immune cells and their targets.

Markus I Diehl, Steven P Wolf, Vytas P Bindokas, Hans Schreiber

Open access · greenAbstract read
In one paragraph

Article in Experimental cell research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. CD4Science immunology · 2024
    Article
  3. One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Markus I DiehlDepartment of Pathology, The University of Chicago, Chicago, IL, 60637, USA.
Steven P WolfDepartment of Pathology, The University of Chicago, Chicago, IL, 60637, USA; Institute of Immunology, Campus Buch, Charité - Universitaetsmedizin Berlin, 13125, Berlin, Germany.
Vytas P BindokasIntegrated Microscopy Core, The University of Chicago, Chicago, IL, 60637, USA.
Hans SchreiberDepartment of Pathology, The University of Chicago, Chicago, IL, 60637, USA; Committee on Cancer Biology and Committee on Immunology, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: hszz@uchicago.edu.
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
PATHOBIOLOGY OF MYELOMA AND ANTI-IDIOTYPIC IMMUNITYR01CA022677 · NCI · UNIVERSITY OF CHICAGO · PI SCHREIBER, HANS · 1985 to 2024
$6.3M
IMMUNOLOGY OF UNIQUE TUMOR-SPECIFIC ANTIGENSR01CA037156 · NCI · UNIVERSITY OF CHICAGO · PI SCHREIBER, HANS · 1985 to 2017
$3.1M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA022677NCI NIH HHS R01 CA037156
6 · The paper itself

Abstract

Understanding interactions between immune cells and their targets is an important step on the path to fully characterizing the immune system, and in doing so, learning how it combats disease. Many studies of these interactions have a narrow focus, often looking only at a binary result of whether or not a specific treatment was successful or only focusing on the interactions between two individual cells. Therefore, in an effort to more comprehensively study multicellular interactions among immune cells and their targets, we used in vitro longitudinal time-lapse imaging and developed an automated cell cluster analysis tool, or macro, to investigate the formation of cell clusters. In particular, we investigated the behavior of cancer-specific CD8

Indexed as

Cell Culture TechniquesAnimalsCell CommunicationCell MovementCluster AnalysisMice, Inbred C57BLT-LymphocytesCancerCell cluster analysisImmune cell interactionsMacro

Identifiers

PMID32439494
PMCPMC7415733
OpenAlexW3027969259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.