Evidence map›Paper›PMID 32439346›Full record

ArticleBehavioural brain research2020

Enriching hippocampal memory function in older adults through video games.

Gregory D Clemenson, Shauna M Stark, Samantha M Rutledge, Craig E L Stark

Open access · greenAbstract read
In one paragraph

Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Science and Videogames: From Scientific Dissemination to Knowledge Production.American journal of human biology : the official journal of the Human Biology Council · 2026
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  12. Not Just How Much, But How Many: Overall and Domain-Specific Activity Variety and Cognitive Functioning in Adulthood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
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  13. Article
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  15. PlayingFrontiers in sports and active living · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gregory D ClemensonDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, United States.
Shauna M StarkDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, United States.
Samantha M RutledgeDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, United States.
Craig E L StarkDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, United States. Electronic address: cestark@uci.edu.
University of California, Irvine · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
High-resolution Structural and Functional Brain Imaging of the Medial Temporal LoR01AG034613 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2009 to 2018
$4.6M
Videogame-based environmental enrichment training for altercations in hippocampal function and memory in middle-aged adultsR21AG056145 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2017 to 2018
$425k
NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG034613NIA NIH HHS R21 AG056145
6 · The paper itself

Abstract

Healthy aging is accompanied by a steady cognitive decline with clear losses in memory. Animal studies have consistently demonstrated that simply modifying an animal's living environment (known as environmental enrichment) can have a positive influence on age-related cognitive decline in the hippocampus. Previously, we showed that playing immersive 3D video games can improve hippocampal-based memory in young healthy adults, suggesting that the exploration of the large open worlds of modern-day video games may act as proxy for environmental enrichment in humans. Here, we replicated our previous video game study in healthy older adults, showing that playing video games for four weeks can improve hippocampal-based memory in a population that is already experiencing age-related decline in memory. Furthermore, we showed that the improvements last for up to four weeks past the intervention, highlighting the potential of video games as intervention for age-related cognitive decline.

Indexed as

Cognitive RemediationEnvironmentVideo GamesAgedAged, 80 and overAgingCognitive DysfunctionFemaleHippocampusHumansMaleMemory DisordersMiddle AgedOutcome Assessment, Health CarePsychomotor PerformanceAgingEnvironmental enrichmentPattern separationSpatial exploration

Identifiers

PMID32439346
PMCPMC7286064
OpenAlexW3024202011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.