Evidence map›Paper›PMID 32439088›Full record

ReviewGastrointestinal endoscopy clinics of North America2020

Multitarget Stool DNA for Average Risk Colorectal Cancer Screening: Major Achievements and Future Directions.

John B Kisiel, Jason D Eckmann, Paul J Limburg

Abstract readReview
In one paragraph

Review in Gastrointestinal endoscopy clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Colon capsule endoscopy: Can it contribute to green endoscopy?World journal of gastrointestinal endoscopy · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Novel Diagnostic Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2022
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John B KisielDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA. Electronic address: Kisiel.john@mayo.edu.
Jason D EckmannDepartment of Internal Medicine, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA. Electronic address: https://twitter.com/JasonEckmannMD.
Paul J LimburgDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA. Electronic address: https://twitter.com/limburg_paul.

Funding

Multi-site Gastrointestinal Cancer Detection by Stool DNA MethylationR37CA214679 · NCI · MAYO CLINIC ROCHESTER · PI KISIEL, JOHN · 2018 to 2024
$2.8M
Multi-cancer Early DetectionR01CA214679 · NCI · MAYO CLINIC ROCHESTER · PI John Kisiel, Niloy Jewel Samadder · 2025 to 2026
$891k
NCI NIH HHS R01 CA214679NCI NIH HHS R37 CA214679
6 · The paper itself

Abstract

After 2 screen-setting studies showing high sensitivity for colorectal cancer and advanced precancerous lesions, multitarget stool DNA testing was endorsed by the US Preventative Services Task Force as a first-line colorectal cancer screening test. Uptake has increased exponentially since approval by the US Food and Drug Administration and Centers for Medicare and Medicaid Services. Adherence to testing is approximately 70%. Patients with positive results have high diagnostic colonoscopy completion rates in single-center studies. The positive predictive value for colorectal neoplasia in postapproval studies is high. Next-generation test prototypes show promise to extend specificity gains while maintaining high sensitivity.

Indexed as

Early Detection of CancerColorectal NeoplasmsDNA MethylationDNA Mutational AnalysisDNA, NeoplasmFecesHemoglobinsHigh-Throughput Nucleotide SequencingHumansMass ScreeningPredictive Value of TestsSensitivity and SpecificityDNA, NeoplasmHemoglobinsColonoscopy/trendsColorectal neoplasms/diagnosisColorectal neoplasms/prevention and controlDNAEarly detection of cancer/methodsNeoplasm/analysisPrecancerous conditions/diagnosisProximal colorectal neoplasia

Identifiers

PMID32439088
PMCPMC10964930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.